How Moringa oleifera Supplementation Affects T-cell Subsets and Circulating Angiogenic, Myeloid, and Endothelial Cells in Mice with Alloxan-induced Diabetes

摘要

Background and Aims: To our knowledge, no study has investigated neither how Moringa leaf extract modulates the immune system in normal nor diabetic subjects. Materials and Methods: Diabetes was induced by a single intraperitoneal dose of alloxan (150 mg/kg). A dose of 100 mg/kg of MO extract was orally administered to diabetic treated mice. The profile of glucose and insulin was evaluated. The activity of superoxide dismutase, catalase, glutathione peroxidase, and glutathione en2ymes was determined. Liver function was monitored by measuring levels of alkaline phosphatase, glutamine pyruvate transaminase, and glutamic oxaloacetic transaminase. The percentage of single-or double-positive cells of each of CD8+/CD4+, CD117+/Sca-1+, Sca-1+/CD34+, CD1 Ib+/Ly6-G+, CD1 lc+/CDl lb+, and CD34+/CD117+ was investigated by flow cytometry in the peripheral blood.