The oligoclonal anti-EGFR antibody MM-151 synergizes with trametinib in KRAS wildtype and mutant colorectal cancer models resistant to conventional monoclonal anti-EGFR antibodies

Landenranta J.; Gerami-Moayed N.; Burenkova O.; Masson K.; Raue A.; Wainszelbaum M.; MacBeath G.

首页> 外文期刊>European journal of cancer: official journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR) >The oligoclonal anti-EGFR antibody MM-151 synergizes with trametinib in KRAS wildtype and mutant colorectal cancer models resistant to conventional monoclonal anti-EGFR antibodies

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The oligoclonal anti-EGFR antibody MM-151 synergizes with trametinib in KRAS wildtype and mutant colorectal cancer models resistant to conventional monoclonal anti-EGFR antibodies

机译：Oligoclonal抗EGFR抗体MM-151在KRAS Wildtype和抗常规单克隆抗EGFR抗体抗性的抗毒素和突变结肠直肠癌模型中促进了曲米菌素的促进

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《European journal of cancer: official journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)》 |2016年第null期|共1页
作者
Landenranta J.; Gerami-Moayed N.; Burenkova O.; Masson K.; Raue A.; Wainszelbaum M.; MacBeath G.;
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Merrimack Discovery Cambridge MA USA;

Merrimack Discovery Cambridge MA USA;

Merrimack Discovery Cambridge MA USA;

Merrimack Discovery Cambridge MA USA;

Merrimack Discovery Cambridge MA USA;

Merrimack Discovery Cambridge MA USA;

Merrimack Discovery Cambridge MA USA;

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正文语种 eng
中图分类肿瘤学;
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专利

1. The oligoclonal anti-EGFR antibody MM-151 synergizes with trametinib in KRAS wildtype and mutant colorectal cancer models resistant to conventional monoclonal anti-EGFR antibodies [J] . Landenranta J., Gerami-Moayed N., Burenkova O., European journal of cancer: official journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR) . 2016,第Null期

机译：寡克隆抗EGFR抗体MM-151与曲美替尼在KRAS野生型和对常规单克隆抗EGFR抗体有抵抗力的突变结肠直肠癌模型中协同作用
2. MM-151 Oligoclonal anti-EGFR antibody combination Treatment of colorectal cancer Treatment of non-small cell lung cancer Treatment of head and neck cancer [J] . Haddley K. Drugs of the Future . 2016,第12期

机译：MM-151寡克隆抗EGFR抗体组合治疗大肠癌非小细胞肺癌的治疗头颈癌的治疗
3. Meta-analysis comparing the efficacy of anti-EGFR monoclonal antibody therapy between KRAS G13D and other KRAS mutant metastatic colorectal cancer tumours [J] . Rowland Andrew, Dias Mafalda M., Wiese Michael D., European journal of cancer: official journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR) . 2016,第Null期

机译：荟萃分析比较了KRAS G13D与其他KRAS突变型转移性结直肠癌肿瘤之间抗EGFR单克隆抗体治疗的疗效
4. A Mathematical Model for Assessing KRAS Mutation Effect on Monoclonal Antibody Treatment of Colorectal Cancer [C] . Sheema Sameen, Roberto Barbuti, Paolo Milazzo, International Conference on Software Engineering and Formal Methods . 2015

机译：评估克拉斯突变对直肠癌单克隆抗体治疗的数学模型
5. Beyond KRAS: Predictive factors of the efficacy of anti-EGFR monoclonal antibodies in the treatment of metastatic colorectal cancer [O] . Alfonso De Stefano, Chiara Carlomagno 2014

机译：超越KRAS：抗EGFR单克隆抗体治疗转移性结直肠癌疗效的预测因素
6. Beyond KRAS: Predictive factors of the efficacy of\ud anti-EGFR monoclonal antibodies in the treatment of\ud metastatic colorectal cancer [O] . De Stefano A, Carlomagno C 2014

机译：超越KRas：ud疗效的预测因素抗EGFR单克隆抗体治疗ud 转移性结直肠癌
7. Systematic Reviews on Selected Pharmacogenetic Tests for Cancer Treatment: CYP2D6 for Tamoxifen in Breast Cancer, KRAS for anti-EGFR antibodies in Colorectal Cancer, and BCR-ABL1 for Tyrosine Kinase Inhibitors in Chronic Myeloid Leukemia. Technology Assessment Report [R] . Terasawa, T., Dahabreh, I., Castaldi, P. J., 2010

机译：针对癌症治疗的选定药物遗传学测试的系统评价：CYp2D6用于乳腺癌中的他莫昔芬，KRas用于结肠直肠癌中的抗EGFR抗体，以及BCR-aBL1用于慢性髓性白血病中的酪氨酸激酶抑制剂。技术评估报告

The oligoclonal anti-EGFR antibody MM-151 synergizes with trametinib in KRAS wildtype and mutant colorectal cancer models resistant to conventional monoclonal anti-EGFR antibodies

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