Experimental Study of Taurine on the Cerebral Dehydrogenase Activity in the Model of Unilateral Cerebral Ischemia

摘要

Ischemic brain affection is a common outcome of different diseases: diabetes mellitus, arterial hypertension, coronary artery disease, etc. (Tanashyan 2007; Suslina et al. 2009). They also could be caused by previously done coronary artery bypass graft (Shrader et al. 2012) and surgeries on the common carotid arteries (Ponomarev et al. 2011). According to statistics, 5-10 % of all human strokes are due to atherosclerotic thrombosis of the left common carotid artery (LCCA) (Mollaev et al. 2013). It is reported that there is significant morphological, biochemical and functional difference between brain hemispheres (Bogolepov and Fokin 2004). If one of the hemispheres is deteriorated during brain ischemia, the functional deficiency will be balanced by the symmetrical structures of the other hemisphere (Smusin et al. 2001).