A Facile One-Pot Greener Synthesis and Antibacterial Activity of 2-Amino-4H-pyran Derivatives

摘要

The development of environmentally benign, efficient, and economical methods for the synthesis of biologically interesting compounds remains a significant challenge in synthetic chemistry. One-pot green synthesis emphasizes the need for environmentally clean synthesis, which involves improvement in selectivity, high atom efficiency, elimination of hazardous reagents, and easy separation with recovery and reuse of reagents. 4H-Pyran derivatives represent an important class of compounds. They are often used in cosmetics and pigments, and utilized as potentially biodegradable agrochemicals. They also constitute a structural unit of many natural products and biologically interesting compounds which possess various pharmacological activities such as antiallergic and antitumor. In our efforts to develop a facile and greener one-pot multi-component reaction, the synthesis of 2-amino-4H-pyrans was achieved under solvent-free conditions using magnesium oxide as a catalyst in very good yields. The reaction catalyst, magnesium oxide, was reused and recycled without any loss of activity and product yields. All the synthesized compounds were screened for in vitro antibacterial activity. Some of these compounds showed complete inhibition of bacterial growth at 128 mug/ml or less, and the rest of the compounds exhibited incomplete inhibition at these concentrations.