Challenges when using real-world bio-data to calibrate simulation systems

摘要

Computer simulations allow us to gain insight into biological systems that would not be possible without destroying or changing the system in significant ways. To ensure that results are relevant, real-world bio-data should be used to calibrate simulations. Real-world data contain uncertainty due to the nature of how it is obtained. This chapter provides various sources on uncertainty and methods to cope with this challenge.