Impact of preoperative leukocyte alteration in surgically-treated early-stage cervical cancer patients with low-risk, intermediate-risk or high-risk factors

摘要

Purpose: The aim of this study was to investigate the prognostic impact of a preoperative leukocyte alteration in patients with surgically-treated early-stage cervical cancer. Materials and Methods: The baseline characteristics and outcome data of early-stage cervical cancer patients who were treated with radical hysterectomy between 1996 and 2011 were collected and retrospectively reviewed. The patients were separated into three risk groups (low-risk, intermediate-risk, and high-risk) according to the pathological risk factors exhibited by their tumors. A Cox proportional hazards regression model was used to investigate the prognostic significance of a preoperative leukocytosis (= 10,000 mu/l). Results: A preoperative leukocytosis was observed in 0.9%, 6.6%, and 8.6% of the patients in the low-risk, intermediate-risk, and high-risk groups, respectively. In multivariate analysis, a preoperative leukocytosis was found to be an independent prognostic factor in intermediate-risk or high-risk groups. Conclusion: The preoperative leukocytosis is an independent predicator of shorter progression-free survival (PFS) in surgically-treated early-stage cervical cancer patients, especially those with intermediate-risk or high-risk factors.