ACI‐1 beta‐lactamase is widespread across human gut microbiomes in Negativicutes due to transposons harboured by tailed prophages

Rands Chris M.; Starikova Elizaveta V.; Brüssow Harald; Kriventseva Evgenia V.; Govorun Vadim M.; Zdobnov Evgeny M

摘要

Summary > Antibiotic resistance is increasing among pathogens, and the human microbiome contains a reservoir of antibiotic resistance genes. Acidaminococcus intestini is the first Negativicute bacterium (Gram‐negative Firmicute) shown to be resistant to beta‐lactam antibiotics. Resistance is conferred by the aci1 gene, but its evolutionary history and prevalence remain obscure. We discovered that ACI‐1 proteins are phylogenetically distinct from beta‐lactamases of Gram‐positive Firmicutes and that aci1 occurs in bacteria scattered across the Negativicute clade, suggesting lateral gene transfer. In the reference A. intestini RyC‐MR95 genome, we found transposons residing within a tailed prophage context are likely vehicles for aci1 's mobility. We found aci1 in 56 (4.4%) of 1,267 human gut metagenomes, mostly hosted within A. intestini , and, where could be determined, mostly within a consistent mobile element constellation. These samples are from Europe, China and the USA, showing that aci1 is distributed globally. We found that for most Negativicute assemblies with aci1 , the prophage observed in A. instestini is absent, but in all cases aci1 is flanked by varying transposons. The chimeric mobile elements we identify here likely have a complex evolutionary history and potentially provide multiple complementary mechanisms for antibiotic resistance gene transfer both within and between cells. </abstract> </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> <div class="translation abstracttxt"> <span class="zhankaihshouqi fivelineshidden" id="abstract"> <span>机译：</span><Abstract XMLNS =“http://www.wiley.com/namespaces/wiley”type =“main”xml：lang =“en”> <标题类型=“main”>概述</ title> >抗生素抗性在病原体中增加，人微生物组含有抗生素抗性基因的储存器。酰氨酸氨基氨基氨基含量</ i>是第一个否定顽固的细菌（革兰氏阴性固体耐压），被证明是对β-内酰胺抗生素的抗性。 ACI1 </ i>基因赋予抗性，但其进化历史和流行率仍然模糊不清。我们发现ACI-1蛋白质是从革兰氏阳性β-内酯的β-内酰胺酶中不同的，并且 ACI1 </ i>发生在散射在否定的抗癌的曲线上的细菌中，表明横向基因转移。在参考文献 a。 Intestini </ i> RYC-MR95基因组，我们发现驻留在尾尾的上下文中的转座子可能是 ACI1的载体的动员。我们发现了56（4.4％）的1,267个人肠道组织中的 aci1 </ i>，主要载于 a。 intestini </ i>，并且可以在哪里确定，主要是在一致的移动元素星座内。这些样本来自欧洲，中国和美国，表明 ACI1 </ i>在全球范围内分发。我们发现，对于具有 ACI1的大多数否定型组件，在 a中观察到的前景。 Instestini </ i>不存在，但在所有情况下， ACI1 </ i>通过不同的转座子侧翼。我们识别在这里的嵌合移动元件可能具有复杂的进化历史，并且可能提供多种互补机制，用于细胞内和之间的抗生素抗性基因转移。 </ p> </ abstract> </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> </div> <div class="record"> <h2 class="all_title" id="enpatent33" > 著录项</h2> <ul> <li> <span class="lefttit">来源</span> <div style="width: 86%;vertical-align: text-top;display: inline-block;"> <a href='/journal-foreign-22868/'>《Environmental microbiology 》</a> <b style="margin: 0 2px;">|</b><span>2018年第6期</span><b style="margin: 0 2px;">|</b> <span>共13页</span> </div> </li> <li> <div class="author"> <span class="lefttit">作者</span> <p id="fAuthorthree" class="threelineshidden zhankaihshouqi"> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Rands Chris M.&option=202" target="_blank" rel="nofollow">Rands Chris M.;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Starikova Elizaveta V.&option=202" target="_blank" rel="nofollow">Starikova Elizaveta V.;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Brüssow Harald&option=202" target="_blank" rel="nofollow">Brüssow Harald;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Kriventseva Evgenia V.&option=202" target="_blank" rel="nofollow">Kriventseva Evgenia V.;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Govorun Vadim M.&option=202" target="_blank" rel="nofollow">Govorun Vadim M.;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Zdobnov Evgeny M&option=202" target="_blank" rel="nofollow">Zdobnov Evgeny M;</a> </p> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zkzz" style="display: none;">展开▼</span> </div> </li> <li> <div style="display: flex;"> <span class="lefttit">作者单位</span> <div style="position: relative;margin-left: 3px;max-width: 639px;"> <div class="threelineshidden zhankaihshouqi" id="fOrgthree"> <p>Department of Genetic Medicine and DevelopmentUniversity of Geneva Medical School and Swiss Institute of BioinformaticsGeneva Switzerland;</p> <p>Department of Molecular Biology and GeneticsFederal Research and Clinical Center of Physical‐Chemical MedicineMoscow Russian Federation;</p> <p>KU Leuven Department of BiosystemsLaboratory of Gene TechnologyLeuven Belgium;</p> <p>Department of Genetic Medicine and DevelopmentUniversity of Geneva Medical School and Swiss Institute of BioinformaticsGeneva Switzerland;</p> <p>Department of Molecular Biology and GeneticsFederal Research and Clinical Center of Physical‐Chemical MedicineMoscow Russian Federation;</p> <p>Department of Genetic Medicine and DevelopmentUniversity of Geneva Medical School and Swiss Institute of BioinformaticsGeneva Switzerland;</p> </div> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zhdw" style="display: none;">展开▼</span> </div> </div> </li> <li> <span class="lefttit">收录信息</span> <span style="width: 86%;vertical-align: text-top;display: inline-block;"></span> </li> <li> <span class="lefttit">原文格式</span> <span>PDF</span> </li> <li> <span class="lefttit">正文语种</span> <span>eng</span> </li> <li> <span class="lefttit">中图分类</span> <span> <a href="https://www.zhangqiaokeyan.com/clc/183.html" title="微生物学">微生物学 ;</a></span> </li> <li class="antistop"> <span class="lefttit">关键词</span> <p style="width: 86%;vertical-align: text-top;"> </p> </li> </ul> </div> </div> <div class="literature cardcommon"> <div class="similarity "> <h3 class="all_title" id="enpatent66">相似文献</h3> <div class="similaritytab clearfix"> <ul> <li class="active" >外文文献</li> <li >中文文献</li> <li >专利</li> </ul> </div> <div class="similarity_details"> <ul > <li> <div> <b>1. </b><a class="enjiyixqcontent" href="/journal-foreign-detail/0704023229664.html">ACI‐1 beta‐lactamase is widespread across human gut microbiomes in Negativicutes due to transposons harboured by tailed prophages</a> <b>[J]</b> . <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Rands Chris M.&option=202" target="_blank" rel="nofollow" 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