Fecal Clostridiales distribution and short‐chain fatty acids reflect bowel habits in irritable bowel syndrome

Gargari Giorgio; Taverniti Valentina; Gardana Claudio; Cremon Cesare; Canducci Filippo; Pagano Isabella; Barbaro Maria Raffaella; Bellacosa Lara; Castellazzi Anna Maria; Valsecchi Chiara; Tagliacarne Sara Carlotta; Bellini Massimo; Bertani Lorenzo; Gambaccini Dario; Marchi Santino; Cicala Michele; Germanà Bastianello; Dal Pont Elisabetta; Vecchi Maurizio; Ogliari Cristina; Fiore Walter; Stanghellini Vincenzo; Barbara Giovanni; Guglielmetti Simone

摘要

Summary >Irritable bowel syndrome (IBS), a common functional gastrointestinal disorder, is classified according to bowel habits as IBS with constipation (IBS‐C), with diarrhea (IBS‐D), with alternating constipation and diarrhea (IBS‐M), and unsubtyped (IBS‐U). The mechanisms leading to the different IBS forms are mostly unknown. This study aims to evaluate whether specific fecal bacterial taxa and/or short‐chain fatty acids (SCFAs) can be used to distinguish IBS subtypes and are relevant for explaining the clinical differences between IBS subcategories. We characterized five fecal samples collected at 4‐weeks intervals from 40 IBS patients by 16S rRNA gene profiling and SCFA quantification. Finally, we investigated the potential correlations in IBS subtypes between the fecal microbial signatures and host physiological and clinical parameters. We found significant differences in the distribution of Clostridiales OTUs among IBS subtypes and reduced levels of SCFAs in IBS‐C compared to IBS‐U and IBS‐D patients. Correlation analyses showed that the diverse representation of Clostridiales OTUs between IBS subtypes was associated with altered levels of SCFAs; furthermore, the same OTUs and SCFAs were associated with the fecal cytokine levels and stool consistency. Our results suggest that intestinal Clostridiales and SCFAs might serve as potential mechanistic biomarkers of IBS subtypes and represent therapeutic targets. </abstract> </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> <div class="translation abstracttxt"> <span class="zhankaihshouqi fivelineshidden" id="abstract"> <span>机译：</span><abstract xmlns =“http://www.wiley.com/namespaces/wiley”type =“main”> <title type =“main”>摘要</ title> >肠易激综合征（IBS），一个常见的功能性胃肠疾病，根据具有便秘（IBS-C）的排便习惯，具有腹泻（IBS-D），具有交替的便秘和腹泻（IBS-M）和未满足的（IBS-U）。导致不同IBS形式的机制主要是未知的。本研究旨在评估特定的粪便细菌分类群和/或短链脂肪酸（SCFA）可用于区分IBS亚型，并涉及解释IBS子类别之间的临床差异。我们以16S rRNA基因分析和SCFA定量为40 IBS患者的4周间隔收集的五个粪便样本。最后，我们研究了粪便微生物签名和宿主生理和临床参数之间IBS亚型中的潜在相关性。与IBS-U和IBS-D患者相比，我们发现IBS亚型中梭菌OTU的分布和IBS-C中的SCFA水平降低的显着差异。相关分析表明，IBS亚型之间的梭菌OTU的多样化表示与SCFA的改变有关;此外，与粪便细胞因子水平和粪便一致性相同的OTU和SCFA。我们的研究结果表明，肠梭菌和SCFA可以作为IBS亚型的潜在机制生物标志物，代表治疗靶标。</ p> </摘要> </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> </div> <div class="record"> <h2 class="all_title" id="enpatent33" > 著录项</h2> <ul> <li> <span class="lefttit">来源</span> <div style="width: 86%;vertical-align: text-top;display: inline-block;"> <a href='/journal-foreign-22868/'>《Environmental microbiology 》</a> <b style="margin: 0 2px;">|</b><span>2018年第9期</span><b style="margin: 0 2px;">|</b> <span>共13页</span> </div> </li> <li> <div class="author"> <span class="lefttit">作者</span> <p id="fAuthorthree" class="threelineshidden zhankaihshouqi"> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Gargari Giorgio&option=202" target="_blank" rel="nofollow">Gargari Giorgio;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Taverniti Valentina&option=202" target="_blank" rel="nofollow">Taverniti Valentina;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Gardana Claudio&option=202" target="_blank" rel="nofollow">Gardana Claudio;</a> <a 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rel="nofollow">Valsecchi Chiara;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Tagliacarne Sara Carlotta&option=202" target="_blank" rel="nofollow">Tagliacarne Sara Carlotta;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Bellini Massimo&option=202" target="_blank" rel="nofollow">Bellini Massimo;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Bertani Lorenzo&option=202" target="_blank" rel="nofollow">Bertani Lorenzo;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Gambaccini Dario&option=202" target="_blank" rel="nofollow">Gambaccini Dario;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Marchi Santino&option=202" target="_blank" rel="nofollow">Marchi Santino;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Cicala Michele&option=202" target="_blank" rel="nofollow">Cicala Michele;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Germanà Bastianello&option=202" target="_blank" rel="nofollow">Germanà Bastianello;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Dal Pont Elisabetta&option=202" target="_blank" rel="nofollow">Dal Pont Elisabetta;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Vecchi Maurizio&option=202" target="_blank" rel="nofollow">Vecchi Maurizio;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Ogliari Cristina&option=202" target="_blank" rel="nofollow">Ogliari Cristina;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Fiore Walter&option=202" target="_blank" rel="nofollow">Fiore Walter;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Stanghellini Vincenzo&option=202" target="_blank" rel="nofollow">Stanghellini Vincenzo;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Barbara Giovanni&option=202" target="_blank" rel="nofollow">Barbara Giovanni;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Guglielmetti Simone&option=202" target="_blank" rel="nofollow">Guglielmetti Simone;</a> </p> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zkzz" style="display: none;">展开▼</span> </div> </li> <li> <div style="display: flex;"> <span class="lefttit">作者单位</span> <div style="position: relative;margin-left: 3px;max-width: 639px;"> <div class="threelineshidden zhankaihshouqi" id="fOrgthree"> <p>Division of Food Microbiology and Bioprocesses Department of Food Environmental and Nutritional SciencesUniversity of MilanMilan Italy;</p> <p>Division of Food Microbiology and Bioprocesses Department of Food Environmental and Nutritional SciencesUniversity of MilanMilan Italy;</p> <p>Division of Food Microbiology and Bioprocesses Department of Food Environmental and Nutritional SciencesUniversity of MilanMilan Italy;</p> <p>Department of Medical and Surgical Sciences Centre for Applied Biomedical ResearchUniversity of BolognaBologna Italy;</p> <p>Dipartimento di biotecnologie e scienze della vitaUniversità degli Studi dell'InsubriaVarese Italy;</p> <p>Department of Medical and Surgical Sciences Centre for Applied Biomedical ResearchUniversity of BolognaBologna Italy;</p> <p>Department of Medical and Surgical Sciences Centre for Applied Biomedical ResearchUniversity of BolognaBologna Italy;</p> <p>Department of Medical and Surgical Sciences Centre for Applied Biomedical ResearchUniversity of BolognaBologna Italy;</p> <p>Department of Clinical Surgical Diagnostic and Pediatric SciencesUniversity of PaviaPavia Italy;</p> <p>Department of PediatricsFondazione IRCCS Policlinico San MatteoPavia Italy;</p> <p>Department of Clinical Surgical Diagnostic and Pediatric SciencesUniversity of PaviaPavia Italy;</p> <p>Gastroenterology Unit Department of GastroenterologyUniversity of PisaPisa Italy;</p> <p>Gastroenterology Unit Department of GastroenterologyUniversity of PisaPisa Italy;</p> <p>Gastroenterology Unit Department of GastroenterologyUniversity of PisaPisa Italy;</p> <p>Gastroenterology Unit Department of GastroenterologyUniversity of PisaPisa Italy;</p> <p>Gastroenterology UnitUniversity Campus Bio‐Medico of RomeRome Italy;</p> <p>Gastroenterology UnitS. Martino HospitalBelluno Italy;</p> <p>Gastroenterology UnitS. Martino HospitalBelluno Italy;</p> <p>Gastroenterology and Digestive Endoscopy Unit IRCCS Policlinico San DonatoSan Donato Milanese Italy;</p> <p>Gastroenterology and Digestive Endoscopy Unit IRCCS Policlinico San DonatoSan Donato Milanese Italy;</p> <p>Sofar S.p.ATrezzano Rosa Italy;</p> <p>Department of Medical and Surgical Sciences Centre for Applied Biomedical ResearchUniversity of BolognaBologna Italy;</p> <p>Department of Medical and Surgical Sciences Centre for Applied Biomedical ResearchUniversity of BolognaBologna Italy;</p> <p>Division of Food Microbiology and Bioprocesses Department of Food Environmental and Nutritional SciencesUniversity of MilanMilan Italy;</p> </div> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zhdw" style="display: none;">展开▼</span> </div> </div> </li> <li> <span class="lefttit">收录信息</span> <span style="width: 86%;vertical-align: text-top;display: inline-block;"></span> </li> <li> <span class="lefttit">原文格式</span> <span>PDF</span> </li> <li> <span class="lefttit">正文语种</span> <span>eng</span> </li> <li> <span class="lefttit">中图分类</span> <span> <a href="https://www.zhangqiaokeyan.com/clc/183.html" title="微生物学">微生物学 ;</a></span> </li> <li class="antistop"> <span class="lefttit">关键词</span> <p style="width: 86%;vertical-align: text-top;"> </p> </li> </ul> </div> </div> <div class="literature cardcommon"> <div class="similarity "> <h3 class="all_title" id="enpatent66">相似文献</h3> <div class="similaritytab clearfix"> <ul> <li class="active" >外文文献</li> <li >中文文献</li> <li >专利</li> </ul> </div> <div class="similarity_details"> <ul > <li> <div> <b>1. </b><a class="enjiyixqcontent" href="/journal-foreign-detail/0704023228535.html">Fecal Clostridiales distribution and short‐chain fatty acids reflect bowel habits in irritable bowel syndrome</a> <b>[J]</b> . <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Gargari Giorgio&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">Gargari 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href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=宋增幅&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,宋增幅</a> <span> <a href="/conference-cn-13765/" target="_blank" rel="nofollow" class="tuijian_authcolor"> . 中国畜牧兽医学会动物微生态学分会第四届第十次全国学术研讨会暨动物微生态企业发展论坛 </a> <span> <span> . 2010</span> </span> </div> </li> <li> <div> <b>7. </b><a class="enjiyixqcontent" href="/academic-degree-domestic_mphd_thesis/020316346538.html">丁酸盐对幽门螺杆菌感染小鼠的炎症、肠道菌群和粪便短链脂肪酸的影响</a> <b>[A] </b> <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=黄雨梅&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . 黄雨梅</a> <span> . 2021</span> </span> </div> </li> </ul> <ul style="display: none;"> <li> <div> <b>1. </b><a class="enjiyixqcontent" href="/patent-detail/061203470421.html">短链脂肪酸酯加氢制低碳醇的催化剂、制法、用途和短链脂肪酸酯加氢制低碳醇的方法</a> <b>[P]</b> . <span> 中国专利： CN105797734B </span> <span> . 2019.09.03</span> </div> </li> <li> <div> <b>2. </b><a 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CHARACTERIZED BY MIXED OR ALTERNATING BOWEL HABITS</a> <b>[P]</b> . <span> 外国专利：  WO2007062837A2 </span> <span> . 2007-06-07</span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：5-HT4激动剂在混合性或交替性肠习性表征的肠易激综合征中的应用 </span> </p> </li> <li> <div> <b>5. </b><a class="enjiyixqcontent" href="/patent-detail/06130434738438.html">USE OF A 5-HT4 AGONIST FOR THE TREATMENT OF IRRITABLE BOWEL SYNDROME CHARACTERIZED BY MIXED OR ALTERNATING BOWEL HABITS</a> <b>[P]</b> . <span> 外国专利：  WO2007062837A3 </span> <span> . 2007-07-19</span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：5-HT4激动剂在混合性或交替性肠习性表征的肠易激综合征中的应用 </span> </p> </li> </ul> </div> </div> </div> <div class="theme cardcommon" style="overflow: auto;display:none"> <h3 class="all_title" 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