Remedial dosing recommendations for delayed or missed doses of lamotrigine in pediatric patients with epilepsy using Monte Carlo simulations

Yu Er-Qian; Jiao Zheng; Wang Chen-Yu; Ding Jun-Jie; Zhang Xiu-Hua

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Remedial dosing recommendations for delayed or missed doses of lamotrigine in pediatric patients with epilepsy using Monte Carlo simulations

机译：使用Monte Carlo模拟，在儿科患者中延迟或错过了癫痫病患者的延迟或错过了癫痫病毒的补救给药推荐

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摘要

Objective: This study investigated the effect of delayed or missed doses on the pharmacokinetics (PK) of lamotrigine (LTG) in children with epilepsy and established remedial dosing recommendations for nonadherent patients.

机译：目的：本研究研究了癫痫患儿延迟或错过剂量对癫痫病毒儿童的药代动力学（PK）的影响，并为非正义患者设立了补救给药推荐。

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来源
《Epilepsy & behavior: E&B》 |2019年第2019期|共9页
作者
Yu Er-Qian; Jiao Zheng; Wang Chen-Yu; Ding Jun-Jie; Zhang Xiu-Hua;
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作者单位

Wenzhou Med Univ Affiliated Hosp 1 Nanbaixiang St Wenzhou 325000 Zhejiang Peoples R China;

Fudan Univ Huashan Hosp Dept Pharm 12 Middle Urumqi Rd Shanghai 200040 Peoples R China;

Fudan Univ Huashan Hosp Dept Pharm 12 Middle Urumqi Rd Shanghai 200040 Peoples R China;

Fudan Univ Childrens Hosp Shanghai 201102 Peoples R China;

Wenzhou Med Univ Affiliated Hosp 1 Nanbaixiang St Wenzhou 325000 Zhejiang Peoples R China;

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原文格式 PDF
正文语种 eng
中图分类脑部疾病;
关键词
Epilepsy; Lamotrigine; Nonadherence; Monte Carlo simulation; Population pharmacokinetics; Remedial dose;

机译：癫痫;乳草嗪;不正常;蒙特卡洛模拟;人口药代动力学;补救剂量;

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专利

1. Remedial dosing recommendations for delayed or missed doses of lamotrigine in pediatric patients with epilepsy using Monte Carlo simulations [J] . Yu Er-Qian, Jiao Zheng, Wang Chen-Yu, Epilepsy & behavior: E&B . 2019,第期

机译：使用Monte Carlo模拟，在儿科患者中延迟或错过了癫痫病患者的延迟或错过了癫痫病毒的补救给药推荐
2. SECONDARY NEUTRON DOSES TO PEDIATRIC PATIENTS DURING INTRACRANIAL PROTON THERAPY: MONTE CARLO SIMULATION OF THE NEUTRON ENERGY SPECTRUM AND ITS ORGAN DOSES [J] . Matsumoto Shinnosuke, Koba Yusuke, Kohno Ryosuke, Health Physics: Official Journal of the Health Physics Society . 2016,第4期

机译：颅内质子治疗期间二次中子剂量给小儿患者：中子能谱及其器官剂量的蒙特卡罗模拟
3. SECONDARY NEUTRON DOSES TO PEDIATRIC PATIENTS DURING INTRACRANIAL PROTON THERAPY: MONTE CARLO SIMULATION OF THE NEUTRON ENERGY SPECTRUM AND ITS ORGAN DOSES [J] . Matsumoto Shinnosuke, Koba Yusuke, Kohno Ryosuke, Health Physics: Official Journal of the Health Physics Society . 2016,第4期

机译：中子中子剂量在颅内质子治疗期间给小儿患者：中子能量谱的蒙特卡罗模拟及其器官剂量
4. Experimental Benchmarking of a Monte Carlo Dose Simulation Code for Pediatric CT [C] . Xiang Li, Ehsan Samei, Terry Yoshizumi, Physics of Medical Imaging pt.2; Progress in Biomedical Optics and Imaging; vol.8 no.29; Proceedings of SPIE-The International Society for Optical Engineering; vol.6510 pt.2 . 2007

机译：儿科CT蒙特卡洛剂量模拟代码的实验基准测试
5. Estimating radiation dose to organs of patients undergoing conventional and novel multidetector CT exams using Monte Carlo simulations. [D] . Angel, Erin. 2009

机译：使用蒙特卡洛模拟估算接受常规和新型多探测器CT检查的患者器官的辐射剂量。
6. Radiation Dose to the Fetus for Pregnant Patients Undergoing Multidetector CT Imaging: Monte Carlo Simulations Estimating Fetal Dose for a Range of Gestational Age and Patient Size [O] . Erin Angel, Clinton V. Wellnitz, Mitchell M. Goodsitt, -1

机译：接受多探测器CT成像的孕妇辐射至胎儿的剂量：蒙特卡洛模拟法估算了不同孕龄和患者规模的胎儿剂量
7. Radiation Dose to the Fetus for Pregnant Patients Undergoing Multidetector CT Imaging: Monte Carlo Simulations Estimating Fetal Dose for a Range of Gestational Age and Patient Size [O] . Angel, Erin, Wellnitz, Clinton V., Goodsitt, Mitchell M., 2008

机译：接受多探测器CT成像的孕妇辐射至胎儿的剂量：蒙特卡洛模拟法估算了不同孕龄和患者规模的胎儿剂量

Remedial dosing recommendations for delayed or missed doses of lamotrigine in pediatric patients with epilepsy using Monte Carlo simulations

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