A Novel Electrochemical Sensor Based on Silsesquioxane/Nickel (II) Phthalocyanine for the Determination of Sulfanilamide in Clinical and Drug Samples

Vanoni Caio Raphael; Winiarski Jo?o Paulo; Nagurniak Glaucio Régis; Magosso Hérica Aparecida; Jost Cristiane Luisa

摘要

Abstract > This paper describes the immobilization of nickel (II) phthalocyanine‐tetrasulfonic acid tetrasodium salt (NiTsPc) in 3‐ n‐ propyl(3‐methylpyridinium) silsesquioxane chloride (Si3Pic + Cl ? ). This hybrid material was synthetized and characterized by 29 Si NMR CP‐MAS, FTIR and DRS. The modified material, designated as Si3Pic + Cl ? /NiTsPc, was used to build carbon paste electrodes to determine sulfanilamide (SFL) by differential pulse voltammetry. The modified electrode showed a higher current response when compared to the bare carbon paste electrode. The evaluation of SFL was possible in the presence of salicylic acid, commonly used in solid ointment compositions in a high concentration. Theoretical calculations using density functional theory were done aiming to shed light at dimerization process at SFL. The oxidation peak increased with increasing concentrations of SFL in the range of 35–301?μmol?L ?1 . The LOD and LOQ values obtained were 12 and 35?μmol?L ?1 of SFL, respectively. The novel electrochemical sensor was successfully applied for the determination of SFL in pet drug samples, urine and serum through the standard addition method. Validation was performed through a comparison with values obtained by the molecular absorption spectrometry method and there were no significant differences in the results, as confirmed by the statistical paired t ‐test. This demonstrates the promise of a new approach for analytical application in clinical and drug samples of sulfonamide compounds. </abstract> </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> <div class="translation abstracttxt"> <span class="zhankaihshouqi fivelineshidden" id="abstract"> <span>机译：</span><Abstract Type =“Main”XML：Lang =“en”> <标题类型=“main”>摘要</标题> >本文描述了镍（II）酞菁 - 四磺酸四胞盐（NITSPC）的固定化在3- N - </ i>丙基（3-甲基吡啶）氯化锡（Si3pic + </ sup> cl -sup>）。通过 29℃，FTIR和DRS合成该杂化材料并表征。用差分脉冲伏安法制造被称为Si3pic + </ sup> Cl + / sup> / nitspc的改性材料。与裸碳浆料电极相比，改性电极显示出更高的电流响应。在水杨酸存在下，可以在高浓度的固体软膏组合物中使用的SFL评价。使用密度泛函理论的理论计算旨在在SFL处的二聚化过程中的脱光。氧化峰随着35-301Ω·μmolα1</ sup>的浓度的浓度增加而增加。获得的LOD和LOQ值分别为12和35Ωμmol？l Δ1/ sup>的sfl。通过标准添加方法成功地应用新型电化学传感器用于测定PET药物样品，尿液和血清中的SFL。通过与分子吸收光谱法测定的比较进行验证，结果没有显着差异，如统计成对的统计相对的</ i> -test。这证明了在磺胺酰胺化合物的临床和药物样品中的分析应用方法的承诺。 </ p> </ abstract> </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> </div> <div class="record"> <h2 class="all_title" id="enpatent33" >著录项</h2> <ul> <li> <span class="lefttit">来源</span> <div style="width: 86%;vertical-align: text-top;display: inline-block;"> <a href='/journal-foreign-22546/'>《Electroanalysis》</a> <b style="margin: 0 2px;">|</b><span>2019年第5期</span><b style="margin: 0 2px;">|</b><span>共9页</span> </div> </li> <li> <div class="author"> <span class="lefttit">作者</span> <p id="fAuthorthree" class="threelineshidden zhankaihshouqi"> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Vanoni Caio Raphael&option=202" target="_blank" rel="nofollow">Vanoni Caio Raphael;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Winiarski Jo?o Paulo&option=202" target="_blank" rel="nofollow">Winiarski Jo?o Paulo;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Nagurniak Glaucio Régis&option=202" target="_blank" rel="nofollow">Nagurniak Glaucio Régis;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Magosso Hérica Aparecida&option=202" target="_blank" rel="nofollow">Magosso Hérica Aparecida;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Jost Cristiane Luisa&option=202" target="_blank" rel="nofollow">Jost Cristiane Luisa;</a> </p> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zkzz" style="display: none;">展开▼</span> </div> </li> <li> <div style="display: flex;"> <span class="lefttit">作者单位</span> <div style="position: relative;margin-left: 3px;max-width: 639px;"> <div class="threelineshidden zhankaihshouqi" id="fOrgthree"> <p>Universidade Federal de Santa CatarinaDepartamento de Química88040-900 Florianópolis – SC Brazil;</p> <p>Universidade Federal de Santa CatarinaDepartamento de Química88040-900 Florianópolis – SC Brazil;</p> <p>Universidade Federal de PelotasDepartamento de FísicaP.O. Box 354 Pelotas – RS Brazil;</p> <p>Universidade Federal de Santa CatarinaDepartamento de Química88040-900 Florianópolis – SC Brazil;</p> <p>Universidade Federal de Santa CatarinaDepartamento de Química88040-900 Florianópolis – SC Brazil;</p> </div> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zhdw" style="display: none;">展开▼</span> </div> </div> </li> <li > <span class="lefttit">收录信息</span> <span style="width: 86%;vertical-align: text-top;display: inline-block;"></span> </li> <li> <span class="lefttit">原文格式</span> <span>PDF</span> </li> <li> <span class="lefttit">正文语种</span> <span>eng</span> </li> <li> <span class="lefttit">中图分类</span> <span><a href="https://www.zhangqiaokeyan.com/clc/4817.html" title="电化学、电解、磁化学">电化学、电解、磁化学;</a></span> </li> <li class="antistop"> <span class="lefttit">关键词</span> <p style="width: 86%;vertical-align: text-top;"> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=sulfa-drugs&option=203" rel="nofollow">sulfa-drugs;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=hybrid material&option=203" rel="nofollow">hybrid material;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=silsesquioxane&option=203" rel="nofollow">silsesquioxane;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=nickel phthalocyanine&option=203" rel="nofollow">nickel phthalocyanine;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=differential pulse voltammetry&option=203" rel="nofollow">differential pulse voltammetry;</a> </p> <div class="translation"> 机译：磺胺类药物;杂交材料;Silsesquio烷;镍酞菁;差分脉冲伏安法; </div> </li> </ul> </div> </div> <div class="literature cardcommon"> <div class="similarity "> <h3 class="all_title" id="enpatent66">相似文献</h3> <div class="similaritytab clearfix"> <ul> <li class="active" >外文文献</li> <li >中文文献</li> <li >专利</li> </ul> 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