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首页> 外文期刊>EMBO reports >A retained intron in the 3′‐ UTRUTR of Calm3Calm3 mRNAmRNA mediates its Staufen2‐ and activity‐dependent localization to neuronal dendrites
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A retained intron in the 3′‐ UTRUTR of Calm3Calm3 mRNAmRNA mediates its Staufen2‐ and activity‐dependent localization to neuronal dendrites

机译：在3'- UTR UTR中的保留内含子平整3 平整3 mRNA mRNA将其Staufen2和活性依赖性定位介导到神经元树枝状内

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Abstract > Dendritic localization and hence local <fc>mRNA</fc> translation contributes to synaptic plasticity in neurons. Staufen2 (Stau2) is a well‐known neuronal double‐stranded <fc>RNA</fc> ‐binding protein (ds <fc>RBP</fc> ) that has been implicated in dendritic <fc>mRNA</fc> localization. The specificity of Stau2 binding to its target <fc>mRNA</fc> s remains elusive. Using individual‐nucleotide resolution <fc>CLIP</fc> ( <fc>iCLIP</fc> ), we identified significantly enriched Stau2 binding to the 3′‐ <fc>UTR</fc> s of 356 transcripts. In 28 (7.9%) of those, binding occurred to a retained intron in their 3′‐ <fc>UTR</fc> . The strongest bound 3′‐ <fc>UTR</fc> intron was present in the longest isoform of Calmodulin 3 ( Calm3 <sub> L </sub> ) <fc>mRNA</fc> . Calm3 <sub> L </sub> 3′‐ <fc>UTR</fc> contains six Stau2 crosslink clusters, four of which are in this retained 3′‐ <fc>UTR</fc> intron. The Calm3 <sub> L </sub> <fc>mRNA</fc> localized to neuronal dendrites, while lack of the 3′‐ <fc>UTR</fc> intron impaired its dendritic localization. Importantly, Stau2 mediates this dendritic localization via the 3′‐ <fc>UTR</fc> intron, without affecting its stability. Also, <fc>NMDA</fc> ‐mediated synaptic activity specifically promoted the dendritic <fc>mRNA</fc> localization of the Calm3 <sub> </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> <div class="translation abstracttxt"> <span class="zhankaihshouqi fivelineshidden" id="abstract"> <span>机译：</span><Abstract Type =“Main”XML：ID =“erw21744334-Abs-Abs-0001”> <标题类型=“main”>抽象</ title> >树枝状定位，因此本地<fc> mrna </ fc>翻译贡献神经元中的突触可塑性。 Staufen2（Stau2）是一种众所周知的神经元双链（DS <FC> RBP </ Fc>）的着名神经元双链<Fc> RNA </ FC> - 粘合蛋白（DS <FC> RBP </ Fc>），其含有在树突式<Fc> mRNA </ Fc>定位中。 Stau2与其目标<Fc> mRNA </ FC> S的特异性仍然难以捉摸。使用单个核苷酸分辨率<Fc>夹子（<Fc> Iclip </ Fc>），我们鉴定了显着富集的Stau2结合356转录物的3'- <Fc> UTR </ Fc> S。在28（7.9％）中，在其3'- <Fc> UTR </ Fc>中的保留内含子发生结合。最强的3'- <Fc> UTR </ FC>内含子存在于钙调蛋白3 </ i>的最长同种型中（平整3 </ i> <sub> l </ i > </ sub>）<fc> mRNA </ FC>。 calm3 </ i> <sub> l </ i> </ sub> 3'- <fc> UTR </ FC>包含六个Stau2 Crosslink群集，其中四个是保留3'- <FC> UTR </ FC>内含子。 平静3 </ i> <sub> l </ i> </ sum> <fc> mRNA </ fc>本地化到神经元树枝状，而缺少3'- <FC> UTR </ FC>内含子损害其树突定位。重要的是，Stau2通过3'- <Fc> UTR </ FC>内含子介导该树突定位，而不会影响其稳定性。此外，<Fc> NMDA </ FC>介导的突触活性明确促进了树枝状<Fc> mRNA 平整3 </ i> <sub> 的定位 </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> </div> <div class="record"> <h2 class="all_title" id="enpatent33" >著录项</h2> <ul> <li> <span class="lefttit">来源</span> <div style="width: 86%;vertical-align: text-top;display: inline-block;"> <a href='/journal-foreign-22522/'>《EMBO reports》</a> <b style="margin: 0 2px;">|</b><span>2017年第10期</span><b style="margin: 0 2px;">|</b><span>共13页</span> </div> </li> <li> <div class="author"> <span class="lefttit">作者</span> <p id="fAuthorthree" class="threelineshidden zhankaihshouqi"> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Sharangdhar Tejaswini&option=202" target="_blank" rel="nofollow">Sharangdhar Tejaswini;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Sugimoto Yoichiro&option=202" target="_blank" rel="nofollow">Sugimoto Yoichiro;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Heraud‐Farlow Jacqueline&option=202" target="_blank" rel="nofollow">Heraud‐Farlow Jacqueline;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Fernández‐Moya Sandra M&option=202" target="_blank" rel="nofollow">Fernández‐Moya Sandra M;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Ehses Janina&option=202" target="_blank" rel="nofollow">Ehses Janina;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Ruiz de los Mozos Igor&option=202" target="_blank" rel="nofollow">Ruiz de los Mozos Igor;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Ule Jernej&option=202" target="_blank" rel="nofollow">Ule Jernej;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Kiebler Michael A&option=202" target="_blank" rel="nofollow">Kiebler Michael A;</a> </p> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zkzz" style="display: none;">展开▼</span> </div> </li> <li> <div style="display: flex;"> <span class="lefttit">作者单位</span> <div style="position: relative;margin-left: 3px;max-width: 639px;"> <div class="threelineshidden zhankaihshouqi" id="fOrgthree"> <p>Division of Cell BiologyLMU MunichMartinsried Germany;</p> <p>Department of Molecular NeuroscienceUniversity College London Institute of NeurologyLondon UK;</p> <p>DK RNA BiologyM.F. Perutz LaboratoriesVienna Austria;</p> <p>Division of Cell BiologyLMU MunichMartinsried Germany;</p> <p>Division of Cell BiologyLMU MunichMartinsried Germany;</p> <p>Department of Molecular NeuroscienceUniversity College London Institute of NeurologyLondon UK;</p> <p>Department of Molecular NeuroscienceUniversity College London Institute of NeurologyLondon UK;</p> <p>Division of Cell BiologyLMU MunichMartinsried Germany;</p> </div> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zhdw" style="display: none;">展开▼</span> </div> </div> </li> <li > <span class="lefttit">收录信息</span> <span style="width: 86%;vertical-align: text-top;display: inline-block;"></span> </li> <li> <span class="lefttit">原文格式</span> <span>PDF</span> </li> <li> <span class="lefttit">正文语种</span> <span>eng</span> </li> <li> <span class="lefttit">中图分类</span> <span><a href="https://www.zhangqiaokeyan.com/clc/179.html" title="分子生物学">分子生物学;</a></span> </li> <li class="antistop"> <span class="lefttit">关键词</span> <p style="width: 86%;vertical-align: text-top;"> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Calm3&option=203" rel="nofollow">Calm3;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=intron&option=203" rel="nofollow">intron;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=neuronal activity&option=203" rel="nofollow">neuronal activity;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=neuronal mRNA regulation&option=203" rel="nofollow">neuronal mRNA regulation;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Stau2&option=203" rel="nofollow">Stau2;</a> </p> <div class="translation"> 机译：CALL3;内含子;神经元活动;神经元mRNA条例;Stau2; </div> </li> </ul> </div> </div> <div class="literature cardcommon"> <div class="similarity "> <h3 class="all_title" id="enpatent66">相似文献</h3> <div class="similaritytab 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href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=赵圣国&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,赵圣国</a> <span> <a href="/conference-cn-9648/" target="_blank" rel="nofollow" class="tuijian_authcolor"> . 中国畜牧兽医学会2011学术年会 </a> <span> <span> . 2011</span> </span> </div> </li> <li> <div> <b>7. </b><a class="enjiyixqcontent" href="/academic-degree-domestic_mphd_thesis/02031875909.html">FcαR在中性粒细胞的亚细胞定位和FcαR剪接体表达分析&依赖于FcαR的双特异性分子在自身免疫疾病治疗中的初步探索</a> <b>[A] </b> <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=尹娜&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . 尹娜</a> <span> . 2007</span> </span> </div> </li> </ul> <ul style="display: none;"> <li> <div> <b>1. </b><a class="enjiyixqcontent" href="/patent-detail/06120111633263.html">具有非FcγR依赖性激动活性的肿瘤坏死因子(TNF)受体超家族(TNFRSF)受体-激活抗体融合蛋白(具有非FcγR依赖性激动活性的TNFRSF受体-激活抗体融合蛋白；TRAAFFIAA)</a> <b>[P]</b> . <span> 中国专利： CN111819198A </span> <span> . 2020-10-23</span> </div> </li> <li> <div> <b>2. </b><a class="enjiyixqcontent" href="/patent-detail/06120106064363.html">外周血白细胞中FC受体介导的肿瘤坏死因子超家族mRNA表达</a> <b>[P]</b> . <span> 中国专利： CN101855367A </span> <span> . 2010-10-06</span> </div> </li> <li> <div> <b>3. </b><a class="enjiyixqcontent" href="/patent-detail/06130428553581.html">The vWFCP functional method of detection which designates mRNA of vWFCP which</a> <b>[P]</b> . <span> 外国专利： <!-- 日本专利： --> JP4369143B2 </span> <span> . 2009-11-18</span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：vWFCP功能检测方法，指定vWFCP的mRNA， </span> </p> </li> <li> <div> <b>4. </b><a class="enjiyixqcontent" href="/patent-detail/06130423333493.html">Enhanced FC receptor-mediated tumor necrosis factor superfamily MRNA expression in peripheral blood leukocytes in patients with rheumatoid arthritis</a> <b>[P]</b> . <span> 外国专利： <!-- 美国专利： 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