Endothelin-1 regulation of immediate early gene expression in cardiac myocytes: negative feedback regulation of interleukin 6 by Atf3 and Klf2

摘要

Activation of intracellular signalling pathways by endothelin-1 Cardiac myocytes are terminally-differentiated cells which withdraw from the cell cycle soon after birth. Subsequent growth results from an increase in size of individual myocytes (i.e. hypertrophy) rather than an increase in cell number. Various stimuli promote cardiac myocyte hypertrophy including peptide growth factors which signal through receptor protein tyrosine kinases (e.g. platelet-derived growth factor, PDGF (Clerk et al., 2006)) and Gq protein-coupled receptor (GqPCR) agonists such as