Association between rheumatoid arthritis and genetic variants of natural resistance‐associated macrophage protein 1 gene: A meta‐analysis

摘要

Abstract Aim To evaluate the association between natural resistance‐associated macrophage protein 1 ( NRAMP 1) polymorphisms and rheumatoid arthritis ( RA ). Method All related studies were retrieved and screened from PubMed, CNKI and Web of Science. Pooled odds ratios ( OR s) and 95% CI s were assessed for the strength of association between NRAMP 1 and RA . Publication bias was measured by Begg's funnel plot and Egger's regression test. The robustness of this meta‐analysis was detected by sensitivity analysis. Results A total of five eligible publications were included in the present meta‐analysis. The polled data showed no association between RA and NRAMP 1 D543N and 1729?+?55del4 in the allele model. However, the relationship between RA and NRAMP 1 INT 4 was statistically significant ( OR 1.65, 95% CI 1.14‐2.38). Genotypic analysis demonstrated that there were no associations between RA and NRAMP 1 D543N, 1729?+?55del4 and INT 4 in homozygous comparison (D543N: OR 0.97, 95% CI 0.15‐6.09; 1729?+?55del4: OR 1.19, 95% CI 0.29‐24.88; INT 4: OR 3.18, 95% CI 0.62‐16.26), dominant model (D543N: OR 1.04, 95% CI 0.61‐61.78; 1729?+?55del4: OR 1.41, 95% CI 0.81‐2.47; INT 4: OR 1.22, 95% CI 0.72‐2.06) and recessive model (D543N: OR 0.93, 95% CI 0.15‐5.91; 1729?+?55del4: OR 0.99, 95% CI 0.26‐3.86; INT 4: OR 2.95, 95% CI 0.61‐14.16). In heterozygous comparison, it no association was shown between RA and NRAMP 1 D543N and INT 4, excepting NRAMP 1 1729?+?55del4 ( OR 1.73, 95% CI 1.17‐2.56). Further subgroup analysis indicated that NRAMP 1 1729?+?55del4 and INT 4 were related to RA in Asia and in the Hardy–Weinberg equilibrium group. There exists no publication bias in this meta‐analysis. Conclusion This meta‐analysis indicated that NRAMP 1 1729?+?55del4 and INT 4 confer susceptibility to RA .