Improved disease activity with fosdagrocorat (PF-04171327), a partial agonist of the glucocorticoid receptor, in patients with rheumatoid arthritis: a Phase 2 randomized study

Stock Thomas; Fleishaker Dona; Wang Xin; Mukherjee Arnab; Mebus Charles

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Improved disease activity with fosdagrocorat (PF-04171327), a partial agonist of the glucocorticoid receptor, in patients with rheumatoid arthritis: a Phase 2 randomized study

机译：改善患有类风湿性关节炎患者的FOSDAGROCORAT（PF-0417171327），糖皮质激素受体的部分激动剂的疾病活性改善：A相随机研究

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摘要

AimTo assess efficacy and safety of fosdagrocorat (PF-04171327), a potential dissociated agonist of the glucocorticoid receptor, in rheumatoid arthritis (RA) patients.

机译：AIMTO评估FOSDAGROCORAT（PF-041717171327），含有类风湿性关节炎（RA）患者的含糖皮质激素受体的潜在解离激动剂的疗效和安全性。

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来源
《International journal of rheumatic diseases》 |2017年第8期|共11页
作者
Stock Thomas; Fleishaker Dona; Wang Xin; Mukherjee Arnab; Mebus Charles;
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作者单位

Pfizer Inc 500 Arcola Rd Collegeville PA 19426 USA;

Pfizer Inc Groton CT 06340 USA;

Pfizer Inc Groton CT 06340 USA;

Pfizer Inc Groton CT 06340 USA;

Pfizer Inc Groton CT 06340 USA;

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原文格式 PDF
正文语种 eng
中图分类全身性疾病;
关键词
arthritis; glucocorticoids; prednisone; randomized controlled trial; rheumatoid;

机译：关节炎;糖皮质激素;泼尼松;随机对照试验;类风湿;

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1. Improved disease activity with fosdagrocorat (PF-04171327), a partial agonist of the glucocorticoid receptor, in patients with rheumatoid arthritis: a Phase 2 randomized study [J] . Stock Thomas, Fleishaker Dona, Wang Xin, International journal of rheumatic diseases . 2017,第8期

机译：改善患有类风湿性关节炎患者的FOSDAGROCORAT（PF-0417171327），糖皮质激素受体的部分激动剂的疾病活性改善：A相随机研究
2. Population Pharmacokinetics of Fosdagrocorat (PF-04171327), a Dissociated Glucocorticoid Receptor Agonist, in Patients With Rheumatoid Arthritis [J] . Weatherley Barry, McFadyen Lynn, Tammara Brinda Clinical and translational science. . 2018,第1期

机译：患有类风湿性关节炎患者的FOSDAGROCORAT（PF-0417171327）的群体药代动力学（PF-0417171327），类风湿性关节炎患者
3. Original article: Fosdagrocorat (PF-04171327) versus prednisone or placebo in rheumatoid arthritis: a randomised, double-blind, multicentre, phase IIb study [J] . Frank Buttgereit, Vibeke Strand, Eun Bong Lee, RMD Open . 2019,第1期

机译：原始文章：类风湿关节炎中的Fosdagrocorat（PF-04171327）与泼尼松或安慰剂的比较：一项随机，双盲，多中心，IIb期研究
4. Deep radiomic prediction with clinical predictors of the survival in patients with rheumatoid arthritis-associated interstitial lung diseases [C] . Radin A. Nasirudin, Janne J. Nappi, Chinatsu Watari, SPIE Medical Imaging Conference . 2018

机译：类风湿关节炎相关性间质性肺疾病患者的深部放射学预测和生存期的临床预测
5. Association between disease activity, attitudes toward exercise and exercise in patients with rheumatoid arthritis. [D] . Wu, Mei-Chun. 2006

机译：类风湿关节炎患者的疾病活动性，运动态度与运动之间的关联。
6. Improved disease activity with fosdagrocorat (PF‐04171327) a partial agonist of the glucocorticoid receptor in patients with rheumatoid arthritis: a Phase 2 randomized study [O] . Thomas Stock, Dona Fleishaker, Xin Wang, -1

机译：类风湿关节炎患者使用糖皮质激素受体局部激动剂fosdagrocorat（PF‐04171327）改善疾病活动：一项2期随机研究
7. Population Pharmacokinetics of Fosdagrocorat (PF-04171327), a Dissociated Glucocorticoid Receptor Agonist, in Patients With Rheumatoid Arthritis [O] . Barry Weatherley, Lynn McFadyen, Brinda Tammara 2017

机译：患有类风湿性关节炎患者的FOSDAGROCORAT（PF-0417171327）的群体药代动力学（PF-0417171327），类风湿性关节炎患者

Improved disease activity with fosdagrocorat (PF-04171327), a partial agonist of the glucocorticoid receptor, in patients with rheumatoid arthritis: a Phase 2 randomized study

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