Hydrogen sulfide acts as a pro‐inflammatory mediator in rheumatic disease

摘要

Abstract Objective Hydrogen sulfide (H 2 S) is a gaseous mediator produced in the body. In experimental models, endogenously produced H 2 S has been shown to have pro‐inflammatory effects. The aim of this study was to investigate whether H 2 S is present in three common rheumatic diseases, rheumatoid arthritis ( RA ), gout and osteoarthritis ( OA ) and to determine if H 2 S levels correlate with disease activity. Methods Patients with RA , gout, OA , and healthy controls ( n? = ? 30 each) were recruited. Plasma and where possible, synovial fluid ( SF ), were obtained. Levels of H 2 S and interleukin‐6 ( IL ‐6) (a known inflammatory marker as a positive control) were determined and assessed for their relationship with disease activity. Results SF ‐H 2 S levels were significantly elevated in both RA and gout when compared to respective plasma levels. Plasma levels of H 2 S were not different from those in healthy controls in patients with either RA or gout. In OA , plasma levels of H 2 S were significantly elevated compared to healthy controls. In RA , SF ‐H 2 S levels correlated with Disease Activity Score ( DAS )‐28 and tender joint count. Conclusion H 2 S is present in the joint and acts as a pro‐inflammatory mediator in rheumatic diseases. H 2 S may be a novel therapeutic target for these conditions.