Obtaining nonspherical poly(alkylcyanoacrylate) nanoparticles by the stretching method applied with a marketed water-soluble film

摘要

This work was aimed to produce elongated nanoparticles of clinical interest by the stretching method. Polymer films prepared from material recovered from the dissolution of a marketed stretchable water-soluble film were loaded with 10% of poly(isobutylcyanoacrylate) nanoparticles. The films were elongated at 50 degrees C to 230% of their initial lengths. The shape factor of the nanoparticles recovered after elongation was consistent with stretching conditions applied on the film. This work has demonstrated the feasibility of the preparation of nonspherical poly(isobutylcyanoacrylate) nanoparticles by the stretching method and described conditions to apply the method.