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Role of formyl peptide receptor 2 in homing of endothelial progenitor cells and therapeutic angiogenesis

机译:甲酰肽受体2在内皮祖细胞归巢和治疗性血管生成中的作用

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摘要

Endothelial progenitor cells (EPCs) hold a great promise as a therapeutic mediator in treatment of ischemic disease conditions. The discovery of EPCs in adult blood has been a cause of significant enthusiasm in the field of endothelial cell research and numerous clinical trials have been expedited. After more than a decade of research in basic science and clinical applications, limitations and new strategies of EPC therapeutics have emerged. With various phenotypes, vague definitions, and uncertain distinction from hematopoietic cells, understanding EPC biology remains challenging. However, EPCs, still hold great hope for treatment of critical ischemic injury as low concern regarding safety can accelerate the clinical applications from basic findings. This review provides an introduction to EPC as cellular therapeutics, which highlights a recent finding that EPC homing was promoted through FPR2 signaling.
机译:内皮祖细胞(EPC)作为治疗缺血性疾病的治疗介质具有广阔的前景。成人血液中EPC的发现一直是引起内皮细胞研究领域极大热情的原因,并且已经加速了许多临床试验。在基础科学和临床应用方面进行了十多年的研究之后,EPC治疗方法的局限性和新策略出现了。由于具有各种表型,模糊的定义以及与造血细胞的不确定区分,因此了解EPC生物学仍然具有挑战性。然而,EPC仍然对治疗严重的缺血性损伤抱有巨大希望,因为对安全性的关注不足可以从基本发现中加速临床应用。这篇综述提供了对作为细胞治疗剂的EPC的介绍,这突显了最近的发现,即EPC归巢通过FPR2信号传导得以促进。

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