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A Pilot Study of 18F-FLT PET/CT in Pediatric Lymphoma

机译:18F-FLT PET / CT在儿科淋巴瘤中的试验研究

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摘要

We performed an observational pilot study of 18F-FLT PET/CT in pediatric lymphoma. Eight patients with equivocal 18F-FDG PET/CT underwent imaging with 18F-FLT PET/CT. No immediate adverse reactions to 18F-FLT were observed. Compared to 18F-FDG, 18F-FLT uptake was significantly higher in bone marrow and liver (18F-FLT SUV 8.6 ± 0.6 and 5.0 ± 0.3, versus 18F-FDG SUV 1.9 ± 0.1 and 3.4 ± 0.7, resp., p < 0.05). In total, 15 lesions were evaluated with average 18F-FDG and 18F-FLT SUVs of 2.6 ± 0.1 and 2.0 ± 0.4, respectively. Nonspecific uptake in reactive lymph nodes and thymus was observed. Future studies to assess the clinical utility of 18F-FLT PET/CT in pediatric lymphoma are planned.
机译:我们对儿科淋巴瘤的18F-FLT / CT进行了观测试验研究。 八名患者患有一定的28F-FDG PET / CT接受了18F-FLT PET / CT的成像。 没有观察到对18F-FLT的立即不良反应。 与18F-FDG相比,骨髓和肝脏18°F-FLT摄取显着高(18F-FLT SUV 8.6±0.6和5.0±0.3,而不是18F-FDG SUV 1.9±0.1和3.4±0.7,P <0.05 )。 总共15例,平均为15°F-FDG和18F-FLT SUV分别评估了15个病变分别为2.6±0.1和2.0±0.4。 观察到反应性淋巴结和胸腺中的非特异性摄取。 未来的研究为了评估18F-FLT PET / CT在儿科淋巴瘤中的临床用途。

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