Application of direct analysis in real time-orbitrap mass spectrometry combined with multivariate data analysis for rapid quality assessment of Yuanhu Zhitong Tablet

摘要

Graphical abstractDisplay OmittedHighlights?Yuanhu Zhitong Tablets from five manufactories were detected by using DART-MS.?Gas temperature and extraction solvent were optimized to obtain high quality MS spectra.?Samples were classified into three groups.?Eleven components that contribute most to the classification were selected as analytical markers.AbstractDirect analysis in real time (DART)-orbitrap mass spectrometry (MS) combined with multivariate data analysis was applied to perform quality control for Yuanhu Zhitong Tablet (YZT). The ionization gas temperature of DART and extraction solvent were