Endometrial Cancers With Activating KRas Mutations Have Activated Estrogen Signaling and Paradoxical Response to MEK Inhibition

Ring Kari L.; Yates Melinda S.; Schmandt Rosemarie; Onstad Michaela; Zhang Qian; Celestino Joseph; Kwan Suet-Ying; Lu Karen H.

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Endometrial Cancers With Activating KRas Mutations Have Activated Estrogen Signaling and Paradoxical Response to MEK Inhibition

机译：具有活化KRAS突变的子宫内膜癌具有激活的雌激素信号和对MEK抑制的矛盾反应

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Objectives: The aims of this study were to determine if activating KRas mutation alters estrogen signaling in endometrial cancer (EC) and to explore the potential therapeutic impact of these alterations.

机译：目的：本研究的目的是确定激活KRAS突变是否改变子宫内膜癌（EC）中的雌激素信号，并探索这些改变的潜在治疗影响。

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来源
《International journal of gynecological cancer: official journal of the International Gynecological Cancer Society》 |2017年第5期|共9页
作者
Ring Kari L.; Yates Melinda S.; Schmandt Rosemarie; Onstad Michaela; Zhang Qian; Celestino Joseph; Kwan Suet-Ying; Lu Karen H.;
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作者单位

Dept Gynecol Oncol &

Reprod Med 1155 Hermann Pressler Dr Unit 1362 Houston TX 77030 USA;

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原文格式 PDF
正文语种 eng
中图分类肿瘤学;
关键词
Endometrial cancer; Estrogen signaling; KRas; MEK inhibitor;

机译：子宫内膜癌;雌激素信号;KRA;MEK抑制剂;

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专利

1. Endometrial Cancers With Activating KRas Mutations Have Activated Estrogen Signaling and Paradoxical Response to MEK Inhibition [J] . Ring Kari L., Yates Melinda S., Schmandt Rosemarie, International journal of gynecological cancer: official journal of the International Gynecological Cancer Society . 2017,第5期

机译：具有活化KRAS突变的子宫内膜癌具有激活的雌激素信号和对MEK抑制的矛盾反应
2. Epithelial-to-Mesenchymal Transition Defines Feedback Activation of Receptor Tyrosine Kinase Signaling Induced by MEK Inhibition in KRAS-Mutant Lung Cancer [J] . Kitai Hidenori, Ebi Hiromichi, Tomida Shuta, Cancer discovery. . 2016,第7期

机译：上皮到间充质转变定义了MERAS抑制在KRAS突变型肺癌中诱导的受体酪氨酸激酶信号的反馈激活
3. Identification of the MEK1(F129L) activating mutation as a potential mechanism of acquired resistance to MEK inhibition in human cancers carrying the B-RafV600E mutation. [J] . Wang H, Daouti S, Li WH, Cancer research: The official organ of the American Association for Cancer Research, Inc . 2011,第16期

机译：鉴定MEK1（F129L）激活突变是在携带B-RafV600E突变的人类癌症中获得获得的对MEK抑制的抗性的潜在机制。
4. Simulations of the EGFR - KRAS - MAPK Signalling Network in Colon Cancer. Virtual Mutations and Virtual Treatments with Inhibitors Have More Important Effects Than a 10 Times Range of Normal Parameters and Rates Fluctuations [C] . Nicoletta Castagnino, Lorenzo Tortolina, Roberto Montagna, International Meeting on Computational Intelligence Methods for Bioinformatics and Biostatistics . 2010

机译：EGFR - KRAS - MAPK信号网络在结肠癌中的模拟。具有抑制剂的虚拟突变和虚拟处理具有比正常参数范围的10倍的更重要的效果和速率波动
5. Small molecule inhibition of activated MAP kinase signaling in human cancers: Biological and therapeutic implications. [D] . Joseph, Eric. 2012

机译：在人类癌症中激活MAP激酶信号转导的小分子抑制：生物学和治疗意义。
6. Endometrial cancers with activating KRas mutations have activated estrogen signaling and paradoxical response to MEK inhibition [O] . Kari L. Ring, Melinda S. Yates, Rosemarie Schmandt, -1

机译：具有激活的KRas突变的子宫内膜癌具有激活的雌激素信号传导和对MEK抑制的矛盾反应
7. Endometrial Cancers With Activating KRas Mutations Have Activated Estrogen Signaling and Paradoxical Response to MEK Inhibition [O] . Kari L. Ring, Melinda S. Yates, Rosemarie Schmandt, 2017

机译：具有活化KRAS突变的子宫内膜癌具有激活的雌激素信号和对MEK抑制的矛盾反应

Endometrial Cancers With Activating KRas Mutations Have Activated Estrogen Signaling and Paradoxical Response to MEK Inhibition

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