Prolonged methamphetamine exposure during a critical period in neonatal Sprague Dawley rats does not exacerbate egocentric and allocentric learning deficits but increases reference memory impairments

摘要

Abstract Children exposed to methamphetamine (MA) in utero have cognitive deficits. MA administration in rats for 5–10?days between postnatal days (P)6 and 20 produces cognitive deficits. The purpose of this study was to determine if extending MA administration by 5?days within P6–20 would exacerbate allocentric (Morris water maze) and egocentric (Cincinnati water maze) learning deficits. Sprague Dawley female and male offspring (split‐litter design) were administered saline (SAL) or MA (10?mg/kg) four times daily from P6 to 20 to create four groups: (a) SAL from P6 to 20, (b) MA from P6 to 20 (MA6–20), (c) MA from P6 to 15 (MA6–15), or (d) MA from P11 to 20 (MA11–20); the latter groups received saline on days they did not receive MA. Egocentric, allocentric, and conditioned freezing tests began on P60. The MA6–15 and MA6–20 groups showed egocentric deficits, all MA groups had allocentric deficits but no differences in conditioned freezing compared with SAL controls. The MA6–15 and MA6–20 groups had similar deficits in learning and memory that were larger than in the MA11–20 group. Learning in both mazes was sex dependent, but no interactions with MA were found. The data demonstrate that extending the exposure period of MA beyond the sensitive periods (P6–15 and P11–20) did not exacerbate the cognitive deficits.