Coexpression Analysis of Transcriptome on AIDS and Other Human Disease Pathways by Canonical Correlation Analysis

摘要

Acquired immune deficiency syndrome is a severe disease in humans caused by human immunodeficiency virus. Several humangenes were characterized as host genetic factors that impact the processes of AIDS disease. Recent studies on AIDS patientsrevealed a series disease is complicating with AIDS. To resolve gene interaction between AIDS and complicating diseases, acanonical correlation analysis was used to identify the global correlation between AIDS and other disease pathway genesexpression. The results showed that HLA-B, HLA-A, MH9, ZNED1, IRF1, TLR8, TSG101, NCOR2, and GML are the keyAIDS-restricted genes highly correlated with other disease pathway genes. Furthermore, pathway genes in several diseases suchas asthma, autoimmune thyroid disease, and malaria were globally correlated with ARGs. It suggests that these diseases are ahigh risk in AIDS patients as complicating diseases.