The Promise of Genomic Studies on Human Diseases: From Basic Science to Clinical Application

摘要

The advances in biotechnologies and efficiency in computational resources have provided unprecedented opportunitiesto study and analyze the genomics of human diseases. Overthe last decade, high-through put experiments studying-omics(e.g., genetics, epigenetics, ortranscriptomics) have been usedto generate informative dataresea rchers can use to testdifferent data-driven hypotheses. A big promise of such highdimensional -omics data is the advancement of biomedicineby effectively translating findings from basic science researchinto clinical application. Designing and conducting genomicexperiments in biomedical research aim to enhance the diagnosis, treatment, and prevention of human diseases. Translating -omics findings into clinical practice requires a flexibleframework to incorporate different -omics data types topredict clinical outcomes inan integrated fashion.