Insights on Genomic and Molecular Alterations in Multiple Myeloma and Their Incorporation towards Risk-Adapted Treatment Strategy: Concise Clinical Review

摘要

Although recent advances in novel treatment approaches and therapeutics have shifted the treatment landscape of multiplemyeloma, it remains an incurable plasma cell malignancy. Growing knowledge of the genome and expressed genomic informationcharacterizing the biologic behavior of multiple myeloma continues to accumulate. However, translation and incorporation of vastmolecularunderstandingofcomplextumorbiologytodeliverpersonalizedandprecisiontreatmenttocuremultiplemyelomahavenot been successful to date. Our review focuses on current evidence and understanding of myeloma biology with characterizationin the context of genomic and molecular alterations. We also discuss future clinical application of the genomic and molecularknowledge, and more translational research is needed to benefit our myeloma patients.