Protective and reparative effects of peptides from soybean beta-conglycinin on mice intestinal mucosa injury

摘要

Peptides derived from alcalase digestion of soybean beta-conglycinin, containing 8.52% carbohydrate, exhibits an inhibition effect on pathogen adhesion or translocation to intestinal cells in vitro. In this study, the protective and reparative effects of beta-conglycinin peptides on intestinal mucosa injury in vivo were studied using mice with dextran sulfate sodium (DSS)-induced intestinal mucosa injury. The results showed that beta-conglycinin peptides contained approximately 21.77% glutamic acid (Glu), and significantly reduced the histological injury in mice both in the protective and reparative experiments. The myeloperoxidase activity of mice treated with beta-conglycinin peptides decreased compared with those treated DSS in the positive control group. Immunohistochemical analysis also showed that beta-conglycinin peptides inhibited the expression of inflammatory factor NF-kappa B/p65. These results suggested that peptides derived from soybean beta-conglycinin exhibited protective and reparative effects on mice intestinal mucosa injury.