Study of Relation between Hyperglycemia and Inflammation in Type 2 Diabetes Mellitus

摘要

Background: Inflammatory responses may have either a causal relationship leading to resistance to insulin or may be intensified by the uncontrolled hyperglycemic state which is reflected by the levels of Glycated Hemoglobin-HbAlc. High sensitivity C-reactive protein (hs-CRP) is considered to be a major prognostic marker in response to tissue injury or infection which can be used to assess inflammatory process in Type 2 DM.Objectives: This study was carried out to examine the association of HbAlc levels with the e hs-CRP levels in type 2 DM subjects. Methods: We included 100 (50 males, 50 females) Type 2 DM subjects (with and without complications) and 100 healthy controls. Blood samples were analysed for the Fasting Plasma Glucose, HbAlc and Serum hs-CRP. Results & Interpretation: The mean Fasting plasma glucose, HbAlc and hs-CRP levels were significantly high (P < 0.001) in type 2 diabetic subjects with complications compared to type 2 diabetic subjects without complications. A significant positive correlation was observed between hs-CRP and HbAlc levels in diabetic subjects with complications (r = + 0.36, P = 0.004).ConcIusion: We concluded that poor glycémie controlprecipitate inflammatory events and complications in Type 2 DM.