Effects of Chloride in the Diet on Serum Bromide Concentrations in Dogs

摘要

Potassium bromide (KBr) is an antiepileptic drug used widely for seizure control in dogs. Diets with high chloride content have been shown to decrease serum bromide concentrations in dogs. However, the relationship between dietary chloride intake and serum bromide concentrations currently remains unknown. The aim of the present study was to clarify the relationship between serum bromide concentration and dietary chloride intake in order to contribute to the treatment of epilepsy in dogs on bromide. Steady-state serum bromide concentrations were measured using a gold chloride method in 23 dogs treated with KBr. The content of chloride (per 1g) was measured using Mohr's method or calculated from the ingredients label provided by the manufacturer. A regression analysis was used to evaluate the relationship between dietary chloride intake (mg/kg/day) and the serum bromide concentration per dose (mu g/ml per mg/kg). Dogs with a higher chloride intake had lower serum bromide concentrations. A strong negative correlation was observed between dietary chloride intake (mg/kg/day) and the serum bromide concentration per dose (mu g/ml per mg/kg) (P & 0.01). These results suggest the importance of considering the dietary content of chloride for KBr-treated dogs and may also assist with the selection of KBr doses and appropriate diets by clinicians for dogs treated with KBr.