Molecular validation of the precision-cut kidney slice (PCKS) model of renal fibrosis through assessment of TGF-beta 1-induced Smad and p38/ERK signaling

Zhang Shouhua; Liu Queling; Xiao Juhua; Lei Jun; Liu Yi; Xu Hongyan; Hong Zhengdong

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Molecular validation of the precision-cut kidney slice (PCKS) model of renal fibrosis through assessment of TGF-beta 1-induced Smad and p38/ERK signaling

机译：通过评估TGF-β1诱导的SMAD和P38 / ERK信号传导，肾纤维化精密切割肾切片（PCKS）模型的分子验证

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Background: The precision-cut kidney slice (PCKS) model appears to be a useful ex vivo model of renal fibrosis. However, little in-depth molecular investigation on the PCKS model has been performed. Therefore, the aim of this study will be to investigate and validate the molecular validity of this model.

机译：背景：精密切割的肾脏切片（PCKS）模型似乎是一种有用的肾纤维化模型。然而，已经进行了对PCKS模型的深入深入分子研究。因此，本研究的目的是调查和验证该模型的分子有效性。

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来源
《International immunopharmacology》 |2016年第null期|共5页
作者
Zhang Shouhua; Liu Queling; Xiao Juhua; Lei Jun; Liu Yi; Xu Hongyan; Hong Zhengdong;
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作者单位

Nanchang Univ Affiliated Hosp 2 Dept Gen Surg Nanchang 330006 Jiangxi Peoples R China;

Nanchang Univ Affiliated Hosp 2 Dept Oncol Nanchang 330006 Jiangxi Peoples R China;

Jiangxi Prov Maternal &

Child Hlth Hosp Dept Ultrasound Nanchang Jiangxi Peoples R China;

Jiangxi Childrens Hosp Dept Gen Surg Nanchang Jiangxi Peoples R China;

Nanchang Univ Affiliated Hosp 2 Dept Urol 1 Minde Rd Nanchang 330006 Jiangxi Peoples R China;

Jiangxi Childrens Hosp Dept Gen Surg Nanchang Jiangxi Peoples R China;

Nanchang Univ Affiliated Hosp 2 Dept Urol 1 Minde Rd Nanchang 330006 Jiangxi Peoples R China;

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原文格式 PDF
正文语种 eng
中图分类药理学;
关键词
Precision-cut kidney slice; PCKS; Renal fibrosis; Smad; Smad2; Smad3; Smad7; ERK; p38;

机译：精密切割肾脏切片;PCKS;肾纤维化;Smad;Smad2;Smad3;Smad7;Erk;P38;

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专利

1. Molecular validation of the precision-cut kidney slice (PCKS) model of renal fibrosis through assessment of TGF-beta 1-induced Smad and p38/ERK signaling [J] . Zhang Shouhua, Liu Queling, Xiao Juhua, International immunopharmacology . 2016,第Null期

机译：通过评估TGF-β1诱导的Smad和p38 / ERK信号传导，对肾纤维化的精密切肾切片（PCKS）模型进行分子验证
2. Precision-cut kidney slices (PCKS) to study development of renal fibrosis and efficacy of drug targeting ex vivo [J] . Bao Tung Pham, Dorenda Oosterhuis, Fariba Poosti, Disease models & mechanisms: DMM . 2015,第10期

机译：精密切割肾切片（PCKS）研究肾纤维化的发展和离体靶向药物的功效
3. Murine Precision-Cut Kidney Slices as an ex vivo Model to Evaluate the Role of Transforming Growth Factor-β1 Signaling in the Onset of Renal Fibrosis [J] . Elisabeth G. D. Stribos, Marc A. Seelen, Harry van Goor, Frontiers in Physiology . 2017,第8期

机译：小鼠精密切肾切片作为评估体外转化生长因子-β1信号在肾纤维化发作中的作用的离体模型
4. Multiwave technology introducing shear wave elastography of the kidney: Pre-clinical study on a kidney fibrosis model and clinical feasibility study on 49 human renal transplants [C] . Gennisson Jean-Luc, Grenier Nicolas, Hubrecht Regis, 2010 IEEE International Ultrasonics Symposium . 2010

机译：引入肾脏剪切波弹性成像的多波技术：肾脏纤维化模型的临床前研究和49例人肾移植的临床可行性研究
5. Murine Precision-Cut Kidney Slices as an ex vivo Model to Evaluate the Role of Transforming Growth Factor-β1 Signaling in the Onset of Renal Fibrosis [O] . Elisabeth G. D. Stribos, Marc A. Seelen, Harry van Goor, 2017

机译：小鼠精确切肾切片作为评估转化生长因子-β1信号在肾纤维化发作中的作用的离体模型
6. Precision-cut kidney slices (PCKS) to study development of renal fibrosis and efficacy of drug targeting ex vivo [O] . Poosti, Fariba, Pham, Bao, Oosterhuis, Dorenda, 2015

机译：精密切割肾脏切片（PCKS）研究肾纤维化的发展和离体靶向药物的功效

Molecular validation of the precision-cut kidney slice (PCKS) model of renal fibrosis through assessment of TGF-beta 1-induced Smad and p38/ERK signaling

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