THE POTENTIAL OF PROTEIN-DETECTING M1CROARRAYS FOR CLINICAL DIAGNOSTICS

摘要

The early and accurate detection of disease is an important issue in the development of new medical technology and is crucial for effective disease treatment. For instance, early stage detection of cancer is crucial for a favorable outcome. In the United States, 72% of lung cancers, 57% of colorectal, and 34% of breast cancers have already metastasized by the time they are detected (G2). Unfortunately, most therapeutics are limited in their effectiveness once a tumor has invaded surrounding tissue and metastasized throughout the body. Another unsolved problem is to develop diagnostic assays which distinguish diseases with similar symptoms but different pathogenic mechanisms, such as Alzheimer's disease, Leury-body disease, Creuzfeldt-Jakob disease, frontotemporal dementia (Gl), and prognostic subgroups in cancers (Jl).