Inhibition of neurogenic and thromboxane A(2)-induced human prostate smooth muscle contraction by the integrin alpha 2 beta 1 inhibitor BTT-3033 and the integrin-linked kinase inhibitor Cpd22

摘要

Introduction Prostate smooth muscle contraction is critical for etiology and treatment of lower urinary tract symptoms in benign prostatic hyperplasia (BPH). Integrins connect the cytoskeleton to membranes and cells to extracellular matrix, what is essential for force generation in smooth muscle contraction. Integrins are composed of different subunits and may cooperate with integrin-linked kinase (ILK). Here, we examined effects of inhibitors for different integrin heterodimers and ILK on contraction of human prostate tissues.