Inhibition of telomerase activity and SK-OV-3/DDP cell apoptosis by rhodium(III) and iron(III) complexes with 4 '-(3-thiophenecarboxaldehyde)-2,2 ':6 ',2 ''-terpyridine

摘要

Two rhodium(III) and iron(III) complexes of 4'-(3-thiophenecarboxaldehyde)-2,2':6',2 ''-terpyridine (tpatpy): [Rh (tpatpy)Cl-3]center dot CH3OH (tpatpy-Rh) and [Fe(tpatpy)Cl-3] (tpatpy-Fe) have been prepared and characterized. Tpatpy-Rh (5.03 +/- 1.15 mu M) and tpatpy-Fe (18.020 +/-.45 mu M) exhibited greater cytotoidcity than the tpatpy ligand (70.11 +/- 0.28 mu M) and cisplatin (61.21 +/- 1.39 mu M) against SK-OV-3/DDP cells. In addition, tpatpy-Rh inhibited telomerase by down-regulation of c-myc and hTERT, as well as induced SK-OV-3/DDP cell arrest in the S phase.