Preparation of platinum(II) complexes with naphthalene imide derivatives and exploration of their in vitro cytotoxic activities

摘要

Two new platinum(II) complexes with naphthalene imide derivatives as the ligands, [Pt(3a)Cl]Cl (3a-Pt) and [Pt(3b)Cl]Cl (3b-Pt), where 3a = 5-(3-(bis(pyridin-2-ylmethyDamino)propoxy)-2-phenyl-1H-benzo[de] isoquinoline-1,3(2H)-dione and 3b = 2-benzyl-5-(3-(bis(pyridin-2-ylmethyDamino)propoxy)-1H-benzo[de] isoquinoline-1,3(2H)-dione, were synthesized and structurally characterized. 3b-Pt showed higher anti-tumor properties in vitro against human non-small cell lung cancer NCI-H460 cells (0.89 +/- 0.25 mu M) than 3a-Pt (11.32 +/- 0.47 mu M) and cisplatin (11.09 +/- 1.01 mu M). In addition, 3b-Pt induced NCI-H460 cell apoptosis through inhibition of the telomerase activity and dysfunction of mitochondria.