A comparative study of two noninvasive positive pressure ventilation modes combined with curosurf in the treatment of respiratory distress syndrome in premature infants

摘要

Objective: To compare the efficacy of two noninvasive positive pressure ventilation modes combined with Curosurf in the treatment of respiratory distress syndrome in premature infants. Methods: A prospective study was conducted on 82 premature infants with neonatal respiratory distress syndrome, including 47 males and 35 females. The infants were divided into two groups using the random number table method, with 41 patients in each group. Non-invasive high-frequency ventilation combined with Curosurf treatment was used in the observation group, and bi-level positive airway pressure ventilation combined with Curosurf treatment was used in the control group. The clinical efficacy in the two groups was observed. The arterial partial pressure of oxygen (PaO2), the arterial partial pressure of carbon dioxide (PaCO2), and the oxygenation index (Ol, PaO2/FiO(2)) were measured before treatment and at 1 hour, 6 hours, 12 hours, 24 hours, and 72 hours after treatment. The non-invasive ventilator treatment time, oxygen inhalation time, hospitalization time, and complications were recorded. Results: The total effective rate in the observation group was 95.12%, which was higher than the total effective rate in the control group (82.93%, P>0.05). After 1 h and 72 h of treatment, the PaO2 in the observation group was higher than it was in the control group (P<0.05). After 1 h, 6 h and 12 h of treatment, the PaCO2 in the observation group was lower than it was in the control group (P<0.05). After 24 h and 72 h of treatment, the Ol in the observation group was higher than it was in the control group (P<0.05). The non-invasive ventilator treatment time, oxygen inhalation time, and hospitalization time in the observation group were lower than they were in the control group (P<0.05). The incidence of complications in the observation group was 4.88%, which was lower than it was in the control group (21.95%, P<0.05). Conclusion: Compared with the combination of bi-level positive airway pressure ventilation and Curosurf treatment, the use of non-invasive high-frequency oscillatory ventilation combined with a pulmonary surfactant can accelerate the time needed for carbon dioxide removal, shorten the treatment time, and reduce the occurrence of complications, which is worthy of further clinical applications.