Association of Infliximab Levels With Mucosal Healing Is Time-Dependent in Crohn's Disease: Higher Drug Exposure Is Required Postinduction Than During Maintenance Treatment

Feng Ting; Chen Baili; Ungar Bella; Qiu Yun; Zhang Shenghong; He Jinshen; Lin Sinan; He Yao; Zeng Zhirong; Ben-Horin Shomron; Chen Minhu; Mao Ren

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Association of Infliximab Levels With Mucosal Healing Is Time-Dependent in Crohn's Disease: Higher Drug Exposure Is Required Postinduction Than During Maintenance Treatment

机译：英夫利昔单抗水平与粘膜愈合的关联是时间依赖于克罗恩疾病：在维持治疗期间，需要优于较高的药物暴露

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Background: Intliximab levels have been reported to be associated with mucosal healing (MH) in Crohn's disease (CD). However, whether the association differs between postinduction (week 14) and maintenance (week 30) has seldom been investigated. We aimed to analyze the association between scrum infliximab trough levels and MH at the 2 different time points.

机译：背景：据报道，Intliximab水平与Crohn疾病（CD）中的粘膜愈合（MH）相关联。但是，关联是否与后导（第14周）与维护（第30周）之间的不同之处。我们旨在分析Scrum Infiximab槽水平与2个不同时间点之间的MH之间的关联。

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《Inflammatory bowel diseases》 |2019年第11期|共9页
作者
Feng Ting; Chen Baili; Ungar Bella; Qiu Yun; Zhang Shenghong; He Jinshen; Lin Sinan; He Yao; Zeng Zhirong; Ben-Horin Shomron; Chen Minhu; Mao Ren;
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作者单位

Sun Yat Sen Univ Affiliated Hosp 1 Dept Gastroenterol 58 Zhongshan Rd 2 Guangzhou 510080;

Sun Yat Sen Univ Affiliated Hosp 1 Dept Gastroenterol 58 Zhongshan Rd 2 Guangzhou 510080;

Tel Aviv Univ Sheba Med Ctr Dept Gastroenterol Tel Hashomer Israel;

Sun Yat Sen Univ Affiliated Hosp 1 Dept Gastroenterol 58 Zhongshan Rd 2 Guangzhou 510080;

Sun Yat Sen Univ Affiliated Hosp 1 Dept Gastroenterol 58 Zhongshan Rd 2 Guangzhou 510080;

Sun Yat Sen Univ Affiliated Hosp 1 Dept Gastroenterol 58 Zhongshan Rd 2 Guangzhou 510080;

Sun Yat Sen Univ Affiliated Hosp 1 Dept Gastroenterol 58 Zhongshan Rd 2 Guangzhou 510080;

Sun Yat Sen Univ Affiliated Hosp 1 Dept Gastroenterol 58 Zhongshan Rd 2 Guangzhou 510080;

Sun Yat Sen Univ Affiliated Hosp 1 Dept Gastroenterol 58 Zhongshan Rd 2 Guangzhou 510080;

Sun Yat Sen Univ Affiliated Hosp 1 Dept Gastroenterol 58 Zhongshan Rd 2 Guangzhou 510080;

Sun Yat Sen Univ Affiliated Hosp 1 Dept Gastroenterol 58 Zhongshan Rd 2 Guangzhou 510080;

Sun Yat Sen Univ Affiliated Hosp 1 Dept Gastroenterol 58 Zhongshan Rd 2 Guangzhou 510080;

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原文格式 PDF
正文语种 eng
中图分类消化系及腹部疾病;
关键词
Crohn's disease; mucosal healing; infliximab;

机译：克罗恩病;粘膜愈合;英夫利昔单抗;

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专利

1. Association of Infliximab Levels With Mucosal Healing Is Time-Dependent in Crohn's Disease: Higher Drug Exposure Is Required Postinduction Than During Maintenance Treatment [J] . Feng Ting, Chen Baili, Ungar Bella, Inflammatory bowel diseases . 2019,第11期

机译：英夫利昔单抗水平与粘膜愈合的关联是时间依赖于克罗恩疾病：在维持治疗期间，需要优于较高的药物暴露
2. Infliximab Trough Levels Are Associated With Mucosal Healing During Maintenance Treatment With Infliximab in Paediatric Crohn's Disease [J] . Kang Ben, Choi So Yoon, Choi Young Ok, Journal of Crohn’s & colitis . 2019,第2期

机译：英夫利昔单抗水平与在儿科克罗恩病的嗜活增生期间的维持治疗期间粘膜愈合有关
3. Mucosal healing of ileal lesions is associated with long-term clinical remission after infliximab maintenance treatment in patients with Crohn's disease [J] . Beppu Takahiro, Ono Yoichiro, Matsui Toshiyuki, Digestive endoscopy: official journal of the Japan Gastroenterological Endoscopy Society . 2015,第1期

机译：回肠病变的粘膜愈合与克罗恩病患者英夫利昔单抗维持治疗后的长期临床缓解相关
4. Importance of mucosal healing in Crohn's disease and ulcerative colitis [C] . G. D HAEN Falk Symposium . 2007

机译：粘膜疾病和溃疡性结肠炎粘膜愈合的重要性
5. FACTORS AFFECTING SERUM LIPID LEVELS IN RENAL PATIENTS UNDERGOING MAINTENANCE HEMODIALYSIS OR CONTINUOUS AMBULATORY PERITONEAL DIALYSIS TREATMENTS (DISEASE, DIET THERAPY). [D] . SALTOS, ETTA ANGEL. 1985

机译：正在进行维持性血液透析或连续性非循环性腹膜透析治疗（疾病，饮食疗法）的肾病患者血清脂水平的影响因素。
6. Higher Postinduction Infliximab Serum Trough Levels Are Associated With Healing of Fistulizing Perianal Crohn’s Disease in Children [O] . Wael El-Matary, Thomas D Walters, Hien Q Huynh, -1

机译：较高的诱导英夫利昔单抗血清谷水平与儿童瘘管性肛周克罗恩病的愈合有关
7. Infliximab Trough Levels Are Associated With Mucosal Healing During Maintenance Treatment With Infliximab in Paediatric Crohn’s Disease [O] . Ben Kang, So Yoon Choi, Young Ok Choi, 2018

机译：英夫利昔单抗水平与在儿科克罗恩病中英夫利昔单抗的维持治疗期间与粘膜愈合有关

Association of Infliximab Levels With Mucosal Healing Is Time-Dependent in Crohn's Disease: Higher Drug Exposure Is Required Postinduction Than During Maintenance Treatment

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