Role of Low Calcium and High Calcium Diet on Adipocyte Metabolism with Respect to Serum Parathyroid Hormone (PTH) Levels in Male Wistar Rats

摘要

Dietary calcium has recently emerged as a potential candidate for therapeutic use against obesity, the major health hazard of the present century. However, there are controversies regarding the role of calcium diet on adipocyte metabolism. We used healthy male wistar rats and fed them with the control diet, low and high calcium diet for three consecutive months. Low calcium diet group showed significantly higher weight gain, accumulation of adipose tissue and increased adiposity index. High calcium diet provided a protection against dyslipidemia by reducing the serum cholesterol and triglyceride. Serum calcium level and PTH level varied significantly in low calcium diet group compared to other two groups. The results of our study revealed that dietary calcium regulates the adiposity of male wistar rats when fed with low and high calcium diet for a long period by altering both lipogenesis and lipolysis pathways within the adipocytes along with changes in serum PTH level.