Correlation of Age with Lung Parameters in Asthmatic Patients with Positive Parental History

摘要

Patients with positive family history of asthma among their first degree relatives have increased risk by 3-6 times. Pulmonary functions were assessed using computerised spirometer RMS Helios 702 in asthmatics aged 20 to 40 years with positive parental history. They were classified based on GINA (Global Initiative for Asthma) 2017 guidelines into controlled, partly controlled and uncontrolled group and subdivided into 20-30 yrs and 31-40 yrs. In this study patients belonging to 20-30 years in uncontrolled group show positive correlation between age and FEV/FEC ratio whereas negative correlation noted in controlled and partly controlled groups. Positive and significant (P<0.05) correlation was found between age and Peak expiratory Flow Rate (PEFR) in controlled and uncontrolled groups among 20-30 years. The uncontrolled group with mild symptoms progress to severe forms within a short period of time due to genetic susceptibility. Therefore earlier the onset of illness, more profound is their impact on pulmonary function.