COGNITIVE ENHANCING ACTIVITY OF VITIS VINIFERA LINN IN RATS WITH EXPERIMENTALLY INDUCED AMNESIA AND ITS INFLUENCE ON CHOLINERGIC SYSTEM OF BRAIN

摘要

The present study investigates the effect of ethanolic Vitis vinifera fruit extract on cognitive function in scopolamine, and electroshock induced amnesia in rats. To explore the potential effect, V. vinifera extract was screened by administrating dose (200 mg/kg) for 7 days using scopolamine-induced amnesia model. Cognition parameters were assessed using elevated plus maze and passive avoidance task method with Mentat as standard by using parameters of step down and transfer latency. Acetylcholinesterases enzyme level from brain homogenate was estimated on 7th day. V. vinifera extract (200 mg/kg) showed increase in escape latency (p<0.001) and time spent in target quadrant (p<0.05) while decrease in transfer latency (p<0.001) was observed in scopolamine induced amnesia. Further, pre-treatment with V. vinifera (200 mg/kg) significantly reversed the behavioral impairment in scopolamine and electroconvulsive shock induced amnesia. Thus, that ethanolic fruit extract of V. vinifera possesses cognition enhancing property in scopolamine and electroshock induced amnesia models.