SYNTHESIS AND ANALGESIC ACTIVITY OF 7-(SUBSTITUTED PHENYL)-9-PHENYL-1H-[1,4]DIAZEPINO [2,3-G] QUINOXALINE-2,3(4H,6H)-DIONES

摘要

A series of 7-substituted phenyl-9-phenyl-1H-[1,4]diazepino[2,3-g]quinoxaline-2,3(4H,6H)-dione (SK1-SK9) was synthesized by the reaction of 6,7-diaminoquinoxaline-2,3(1H,4H)-dione 3 with substituted chalcone with good yield and characterized by elemental and spectral analysis (IR, ~1H NMR, Mass). The synthesized compounds were screened for analgesic activity by tail immersion method. The results revealed that the compound SK6 was significant from this series.