FORMULATION AND IN VITRO EVALUATION OF GEL BASED POLYHERBAL VAGINAL WASH

摘要

Vaginal Infection is quite common in India, a multi-city study estimated that more than 90% of women between the ages 25 and 35 suffer with vaginal infection and 93% do not follow the best personal hygiene practices. The vaginal yeast infection is caused by Candida albicans. Which is characterized by Itching, irritation in tissues at the vaginal opening (vulva), burning sensation, redness /swelling of the vulva, vaginal pain .soreness, vaginal rash, watery vaginal discharge . The objective of the present study was to develop poly-herbal vaginal wash for prevention of Candida albicans infection. Aqueous extracts of Azadirachtaindica leaf, Ocimum Sanctum leaf and Sapindus emarginatus were formulated in an aqueous based carbopol-940 (1%w/w) gel system. Prepared poly herbal vaginal wash formulation was evaluated for their physicochemical properties like texture evaluation, pH determination, viscosity and in vitro Antifungal activity were determined along with short term stability studies. The formulated gel based poly-herbal vaginal wash had acceptable physical parameters that showed that they were compatible and in addition to this, these formulations passed the short-term stability studies. The in vitro antifungal activity studies showed that the formulated gel based vaginal wash showed significantly strong activity against C. albicans. Thus, the present study concludes that the formulated herbal vaginal wash is efficient antifungal formulations for the C. albicans vaginal infection.