Antimicrobial, Antioxidant and DNA Interaction Studies of Water-soluble Complexes of Schiff Base Bearing Morpholine Moiety

摘要

A novel series of metal (II) complexes, [CuL(AcO)]center dot H2O (1), [CoL(AcO)]center dot 4H(2)O (2), [MnL(AcO)]center dot 4H(2)O (3), [NiL(AcO)]center dot 4H(2)O (4) and [ZnL(AcO)]center dot 2H(2)O (5) have been synthesized from 2-(2-morpholinoethylimino) methyl)phenol Schiff base ligand in a 1:1 molar ratio. The resulting compounds were characterized using various physical, chemical and spectral studies. The spectral results indicated square planar geometry around the metal (II) ion and found to possess [ML] stoichiometry. Complexes (1), (2) and (4) exhibited potent antimicrobial, antioxidant and DNA cleavage activities as compared to complexes (3) and (5). In vitro DNA binding properties of complexes (1-5) have been carried out employing the electronic absorption technique. The calculated intrinsic binding constant (Kb) values for the complexes were in the order of 1.3512x105 (1)2.9843x104 (2)1.6432x104 (4)4.2280x103 (5)2.9100x103 M-1 (3) and the DNA binding affinity values of the complexes obtained by the viscosity titration measurements were in the order of (1)(2)(4)(5)(3). The observed results suggested that the complexes (1-5) bind to DNA via intercalation.