Synthesis of 1,2,4-triazole,1,3,4-thiadiazole and 1,3,4-oxadiazole derivatives of 6-nitrobenzimidazole

摘要

A series of new 5-(6'-nitrobenzimidazole-1-ylmethyl-1,2,4-triazoles 5,8,1,3,4-triadiazole 9, and 1,3,4-oxadiazole 10 has been synthesized from 6-nitrobenzimidazole I via 1-N-(6'-nitrobenzimidazole-1-carbonylmethyl)-4-phenyl-3-thiosemicarbazide 6. The thiosemicarbazides have been readily obtained from 6-nitrobenzimidazole-1-acetic acid hydrazide 3 in good yield. These compounds have been characterized on the basis of elemental analyses, IR,NMR and MS.