Convenient method for synthesis of chiral C-1-symmetric pyrrolidine derivative

摘要

Pyrrolidine derivatives are saturated N-heterocyclic compounds widely present in a large number of natural products, alkaloids and biologically active compounds. In this article, is reported the facile synthesis of chiral C-1-symmetric (S)-2-(anthracen-10-y1)-14(R)-1-phenylethy)pyrrolidine and (R)-2(anthracen-10-y1)-14(S)-1-phenylethyl)pyrrolidine diastereomers. These pyrrolidine derivatives are extremely useful for asymmetric transformations and enantioselective synthesis of chiral allenes.