Synthesis and biological activtiy of pyrazino[3,2,1-j,k]carbazoles

摘要

1-Oxo-1,2,3,4-tetrahydrocarbazole derivatives 1a-d have been reacted with ethanolamine to yield the respective ketimines 2a-d which on reduction with sodium borohydride furnish the corresponding amino derivatives 3a-d. The pyrazino[3,2,1-j,k]carbazole derivatives 4a-d are obtained by teh cyclisation of 3a-d using ammonium chloride in diphenyl ether. Compounds 4a-d have been tested for their antimicrobial activity using chloramphenicol as a reference compound.