Proteomics characterization of CENP-B epitope in Moroccan scleroderma patients with anti-centromere autoantibodies

摘要

Background: Anti-centromere auto-antibodies (ACA) have been described as a marker in Systemic sclerosis (SSc) disease. CENP-B is the major centromere auto-antigen recognized by SSc patients with positive ACA. Our aim was to characterize the major epitope involved in the anti-CENP-B immune response of Moroccan SSc patients.