Differences in cell marker expression by equine bone marrow-derived mesenchymal stem cells associated with blood antigen typeand breed.

摘要

There is significant variability in the clinical outcomes following therapeutic use of mesenchymal stem cells (MSCs) for equine musculoskeletal disease. Among the possible causes are differences in the immunogenic response to MSCs. The characterization of MSCs from different donor sources is important in the identification of less immunogenic allogeneic donor MSCs, and may facilitate standardisation of clinical treatments. The aim of this study was to define marker expression differences between twobreeds, and horses with different erythrocyte antigen profiles.