Achievement of low density lipoprotein (LDL) cholesterol targets in primary and secondary prevention: Analysis of a large real practice database in Italy

Presta Vivianne; Figliuzzi Ilaria; Miceli Francesca; Coluccia Roberta; Fogacci Federica; Cicero Arrigo Francesco Giuseppe; Ferrucci Andrea; Borghi Claudio; Tocci Giuliano; Guida Pietro; Avogaro Angelo; Comaschi Marco; Corsini Alberto; Cortese Claudio; Giorda Carlo Bruno; Manzato Enzo; Medea Gerardo; Mureddu Gian Francesco; Riccardi Gabriele; Titta Giulio; Ventriglia Giuseppe; Zito Giovanni Battista; Volpe Massimo

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Achievement of low density lipoprotein (LDL) cholesterol targets in primary and secondary prevention: Analysis of a large real practice database in Italy

机译：初级和二次预防中低密度脂蛋白（LDL）胆固醇靶标的成果：意大利大型真实实践数据库分析

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Background and aims: Target and intensity of low-density lipoprotein cholesterol (LDL-C) lowering therapy should be tailored according to the individual global cardiovascular (CV) risk. We aimed at retrospectively evaluating real-life LDL-C goal attainment and predictive factors for predefined LDL-C therapeutic goals both in primary and secondary prevention.

机译：背景和目标：应根据个体全球心血管（CV）风险量定制降低脂蛋白胆固醇（LDL-C）降低治疗的靶点和强度。我们旨在回顾性地评估现实生活的LDL-C目标达到和预测因素，用于预定义的LDL-C治疗目标均在初级和二级预防中。

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来源
《Atherosclerosis 》 |2019年第2019期| 共9页
作者
Presta Vivianne; Figliuzzi Ilaria; Miceli Francesca; Coluccia Roberta; Fogacci Federica; Cicero Arrigo Francesco Giuseppe; Ferrucci Andrea; Borghi Claudio; Tocci Giuliano; Guida Pietro; Avogaro Angelo; Comaschi Marco; Corsini Alberto; Cortese Claudio; Giorda Carlo Bruno; Manzato Enzo; Medea Gerardo; Mureddu Gian Francesco; Riccardi Gabriele; Titta Giulio; Ventriglia Giuseppe; Zito Giovanni Battista; Volpe Massimo;
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作者单位

Univ Rome Sapienza St Andrea Hosp Fac Med &

Psychol Dept Clin &

Mol Med Hypertens Unit Div;

Univ Rome Sapienza St Andrea Hosp Fac Med &

Psychol Dept Clin &

Mol Med Hypertens Unit Div;

Univ Rome Sapienza St Andrea Hosp Fac Med &

Psychol Dept Clin &

Mol Med Hypertens Unit Div;

IRCCS Neuromed Pozzilli IS Italy;

Univ Bologna St Orsola Malpighi Hosp Med &

Surg Sci Dept Bologna Italy;

Univ Bologna St Orsola Malpighi Hosp Med &

Surg Sci Dept Bologna Italy;

Univ Rome Sapienza St Andrea Hosp Fac Med &

Psychol Dept Clin &

Mol Med Hypertens Unit Div;

Univ Bologna St Orsola Malpighi Hosp Med &

Surg Sci Dept Bologna Italy;

Univ Rome Sapienza St Andrea Hosp Fac Med &

Psychol Dept Clin &

Mol Med Hypertens Unit Div;

Univ Bari Emergency &

Organ Transplantat Dept Cardiol Unit Bari Italy;

Univ Padua Chair Metab Dis Dept Clin &

Expt Med Padua Italy;

Univ Genoa San Martino Hosp Dept Emergency Genoa Italy;

Univ Milan Dept Pharmacol Sci Milan Italy;

Univ Roma Tor Vergata Dept Internal Med Rome Italy;

ASL Turin 5 Metab &

Diabet Unit Chiari Italy;

Univ Padua Dept Med &

Surg Sci Padua Italy;

Italian Coll Gen Practice SIMG Florence Italy;

San Giovanni Addolorata Hosp Dept Cardiovasc Dis Rome Italy;

Univ Napoli Federico II Div Endocrinol &

Metab Dis Naples Italy;

Italian Federat Gen Med Turin Italy;

Italian Coll Gen Practice SIMG Florence Italy;

Assoc Nazl Cardiol Ambulatoriali ARCA Rome Italy;

ASL Napoli 3 Sud Cardiol Unit Pompei NA Italy;

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原文格式 PDF
正文语种 eng
中图分类心脏、血管（循环系）疾病 ;
关键词
Low-density lipoprotein cholesterol; Hypercholesterolemia; High cardiovascular risk; European SCORE; Lipid-lowering therapy; Therapeutic targets;

机译：低密度脂蛋白胆固醇;高胆固醇血症;高心血管风险;欧洲分数;脂质降低治疗;治疗目标;

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专利

1. Achievement of low density lipoprotein (LDL) cholesterol targets in primary and secondary prevention: Analysis of a large real practice database in Italy [J] . Presta Vivianne, Figliuzzi Ilaria, Miceli Francesca, Atherosclerosis . 2019 ,第期

机译：初级和二次预防中低密度脂蛋白（LDL）胆固醇靶标的成果：意大利大型真实实践数据库分析
2. Comparison of the effects of two low-density lipoprotein cholesterol goals for secondary prevention after acute myocardial infarction in real-world practice: >= 50% reduction from baseline versus <70 mg/dL [J] . Cho Kyung Hoon, Jeong Myung Ho, Park Kyung Woo, International Journal of Cardiology . 2015 ,第Null期

机译：在实际操作中比较两种低密度脂蛋白胆固醇目标在急性心肌梗死后二级预防中的作用：与基准值相比减少70％/ dL，而对低于70 mg / dL
3. Non-high-density lipoprotein cholesterol, guideline targets, and population percentiles for secondary prevention in 1.3 million adults: The VLDL-2 study (very large database of lipids) [J] . ElshazlyM.B., MartinS.S., BlahaM.J., Journal of the American College of Cardiology . 2013 ,第21期

机译：非高密度脂蛋白胆固醇，指导目标以及在130万成年人中进行二级预防的人群百分位数：VLDL-2研究（非常大的脂质数据库）
4. Changes of Vascular Wall and Total Cholesterol, High Density Lipoprotein, Oxidized low Density Lipoprotein, Nitric Monoxide and Lipide Peroxidation in Serum after Arcuate Nucleus Lesioned [C] . HE Ying-Ying, rnWANG Xiao-Chang, rnFAN Xiao-Yuan, The 1st International Symposium on Sectional and Imaging Anatomy . 2007

机译：弓形核病变后血清中血管壁和总胆固醇，高密度脂蛋白，氧化型低密度脂蛋白，一氧化氮和脂质过氧化的变化
5. Sortilin as a novel regulator of plasma cholesterol, very-low density lipoprotein secretion and LDL catabolism. [D] . Strong, Alanna. 2012

机译：Sortilin是一种新型的血浆胆固醇，极低密度脂蛋白分泌和LDL分解代谢调节剂。
6. Measurement of Low‐Density Lipoprotein Cholesterol Levels in Primary and Secondary Prevention Patients: Insights From the PALM Registry [O] . Angela M. Lowenstern, Shuang Li, Ann Marie Navar, 2018

机译：一级和二级预防患者低密度脂蛋白胆固醇水平的测量：PALM注册表的见解
7. COMPARISON OF CARDIOVASCULAR EVENTS BETWEEN PATIENTS ACHIEVING LOW-DENSITY LIPOPROTEIN PARTICLE TARGETS AND PATIENTS ACHIEVING LOW-DENSITY LIPOPROTEIN CHOLESTEROL TARGETS IN A MIXED PRIMARY/SECONDARY PREVENTION SAMPLE [O] . Toth Peter P., Grabner Michael, Punekar Rajeshwari, 2015

机译：混合初级/二级预防样本中实现低密度脂蛋白颗粒目标的患者和实现低密度脂蛋白胆固醇目标的患者的心血管事件的比较

Achievement of low density lipoprotein (LDL) cholesterol targets in primary and secondary prevention: Analysis of a large real practice database in Italy

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