I-2/TBPB Mediated Oxidative Reaction to Construct of Imidazo[1,5-alpha]pyridines under Metal-Free Conditions

摘要

A new method for the synthesis of imidazo[1,5-alpha]pyridines, one of the most important N-heterocyclic compounds due to their wide application, was reported in this study. Specifically, using I-2 as a non-metal catalyst and TBPB as an oxidant can efficiently facilitate the synthesis and avoid the use of a metal catalyst. The reaction between ethyl (E)-2-(benzylideneamino)acetate and pyridine represents an unprecedented 1,3-diolar cycloaddition in highly straightforward process with great value.