Asymmetric Synthesis of Indoline-Benzodiazepine Scaffold Catalyzed by Chiral Imidodiphosphoric Acids

摘要

Chiral indoline-benzodiazepines were synthesized via an enantioselective Pictet-Spengler-type reaction catalyzed by chiral imidodiphosphoric acids. A variety of substitution patterns were achieved at room temperature by using 5 mol% catalysts with high yields (up to 97%) and enantioselectivities (up to 99% ee).