Chemoselective Cleavage of C(CO)-C Bond: Molecular Iodine-Catalyzed Synthesis of Quinazolines through sp(3) C-H Bond Functionalization of Aryl Methyl Ketones

摘要

In this work, we report a chemoselective C(CO)-C bond cleavage of aryl methyl ketones in the presence of molecular iodine. The in situ generated keto aryl fragment combined with o-aminobenzyl amines to give quinzolines through a C-H/N-H oxidative tandem cyclization. Various derivatives of quinazolines could be synthesized in good to excellent yields under transition-metal- and additive-free conditions.