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Genetic background of aggressive behaviour in dogs.

机译:狗的攻击行为的遗传背景。

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The background of aggression is very complicated and the basis of its occurrence has not been well explained yet. It is thought that tendency to aggressiveness is an effect of both environmental and genetic factors. Aggression is a very undesirable behavioural trait in dogs living with humans. The aim of this study was to determine the relationship between two polymorphisms: DRD4 intron II VNTR and C/T substitution in exon I HTR2B genes and aggressive behaviour in dogs. The VNTR polymorphism in the DRD4 gene was detected by agarose gel electrophoresis following PCR amplification, whereas C/T substitution in the HTR2B gene was analysed using amplification created restriction site-polymerase chain reaction (ACRS-PCR). A total of 121 dogs of several breeds were analyzed. All animals were classified based on a veterinary interview and observation in two groups: aggressive (n=21) and non-aggressive (n=100). Significant differences in DRD4 genotype frequencies between aggressive and non-aggressive dogs were observed (P<0.05). The study provides a clear evidence of an association of VNTR polymorphism within intron II of the DRD4 gene with the occurrence of aggressive behaviour in dogs. Moreover, the findings give good justification for further research aimed at evaluation of the possibility of using this genetic marker in Marker-assisted Selection.
机译:侵略的背景非常复杂,其发生的基础尚未得到很好的解释。据认为,攻击性倾向是环境和遗传因素的影响。攻击性是与人一起生活的狗非常不希望的行为特征。这项研究的目的是确定两个多态性之间的关系:DRD4内含子II VNTR和外显子I HTR2B基因中的C / T取代与狗的攻击行为。 PCR扩增后,通过琼脂糖凝胶电泳检测DRD4基因的VNTR多态性,而HTR2B基因中的C / T取代则使用扩增产生的限制性位点-聚合酶链反应(ACRS-PCR)进行分析。共分析了121个不同品种的狗。根据兽医的采访和观察,将所有动物分为两组:攻击性(n = 21)和非攻击性(n = 100)。在攻击性和非攻击性狗之间观察到DRD4基因型频率的显着差异(P <0.05)。这项研究提供了明确的证据,表明DRD4基因内含子II中的VNTR多态性与狗的攻击行为有关。而且,这些发现为进一步的研究提供了很好的理由,该研究旨在评估在标记辅助选择中使用这种遗传标记的可能性。

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